• 3171 Citations

Research output per year

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Personal profile

Research interests

The main research interest of my lab is to understand the relationship and signaling crosstalk between inflammation and cancer. Chronic inflammation is a major predisposing factor for many human cancers. Conversely, cancers are often referred to as “wounds that never heal” due to the pro-inflammatory nature of tumor cells which over time, create a fibrostromal milieu that supports tumor cell survival, promotes invasion, subverts host immunity and protects tumor cells against chemotherapeutics or radiation. Understanding the pro-inflammatory mechanism of tumor cells will facilitate development of therapeutics that can halt or even reverse this process to improve treatment outcome.

Areas of Clinical Interest

Gastrointestinal oncology, colorectal cancer, pancreatic cancer, hepatobiliary cancer, novel therapeutics, clinical trial.

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Research Output

  • 3171 Citations
  • 30 Article
  • 9 Review article
  • 3 Chapter
  • 1 Editorial

Assessment of Hepatic Arterial Infusion of Floxuridine in Combination with Systemic Gemcitabine and Oxaliplatin in Patients with Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial

Cercek, A., Boerner, T., Tan, B. R., Chou, J. F., Gönen, M., Boucher, T. M., Hauser, H. F., Do, R. K. G., Lowery, M. A., Harding, J. J., Varghese, A. M., Reidy-Lagunes, D., Saltz, L., Schultz, N., Kingham, T. P., D'Angelica, M. I., Dematteo, R. P., Drebin, J. A., Allen, P. J., Balachandran, V. P. & 11 others, Lim, K. H., Sanchez-Vega, F., Vachharajani, N., Majella Doyle, M. B., Fields, R. C., Hawkins, W. G., Strasberg, S. M., Chapman, W. C., Diaz, L. A., Kemeny, N. E. & Jarnagin, W. R., Jan 2020, In : JAMA oncology. 6, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

  • 10 Scopus citations

    Deciphering the role of innate immune NF-κB pathway in pancreatic cancer

    Khurana, N., Dodhiawala, P. B., Bulle, A. & Lim, K. H., Sep 2020, In : Cancers. 12, 9, p. 1-21 21 p., 2675.

    Research output: Contribution to journalReview article

    Open Access
  • Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

    Jiang, H., Liu, X., Knolhoff, B. L., Hegde, S., Lee, K. B., Jiang, H., Fields, R. C., Pachter, J. A., Lim, K. H. & Denardo, D. G., Jan 1 2020, In : Gut. 69, 1, p. 122-132 11 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations

    FOLFIRINOX for the Treatment of Advanced Gastroesophageal Cancers: A Phase 2 Nonrandomized Clinical Trial

    Park, H., Jin, R. U., Wang-Gillam, A., Suresh, R., Rigden, C., Amin, M., Tan, B. R., Pedersen, K. S., Lim, K. H., Trikalinos, N. A., Acharya, A., Copsey, M. L., Navo, K. A., Morton, A. E., Gao, F. & Lockhart, A. C., 2020, (Accepted/In press) In : JAMA oncology.

    Research output: Contribution to journalArticle

  • Phase Ib/II study combining tosedostat with capecitabine in patients with advanced pancreatic adenocarcinoma

    Grierson, P., Teague, A., Suresh, R., Lim, K. H., Amin, M., Pedersen, K., Tan, B., Huffman, J., Boice, N., Du, L., Liu, J., Lockhart, A. C. & Wang-Gillam, A., Feb 1 2020, In : Journal of Gastrointestinal Oncology. 11, 1, p. 61-67 7 p.

    Research output: Contribution to journalArticle