Personal profile
Research interests
The main research interest of my lab is to understand the relationship and signaling crosstalk between inflammation and cancer. Chronic inflammation is a major predisposing factor for many human cancers. Conversely, cancers are often referred to as “wounds that never heal” due to the pro-inflammatory nature of tumor cells which over time, create a fibrostromal milieu that supports tumor cell survival, promotes invasion, subverts host immunity and protects tumor cells against chemotherapeutics or radiation. Understanding the pro-inflammatory mechanism of tumor cells will facilitate development of therapeutics that can halt or even reverse this process to improve treatment outcome.
Clinical interests
Gastrointestinal oncology, colorectal cancer, pancreatic cancer, hepatobiliary cancer, novel therapeutics, clinical trial.
Mentoring
The lab culture encourages free exploration, and students are welcome to gradually develop their own thinking and strategies. High degrees of motivation and independence are greatly appreciated. On the other hand, the PI is always available for advice or open discussion.
This is an international lab that has students and postdocs from several different countries. Women and minorities are a large component of the lab and have contributed to a major part of our achievements in the past.
Available to Mentor:
- PhD Students
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Therapeutic reprogramming of tumour-associated macrophages in pancreatic cancer using a cytotoxic CCR2-targeted nanotheranostic
Somani, V. K., Zhang, X., Chen, T. H. P., Bulle, A., Bansod, S., Li, L., Geng, Y., Kang, L. I., Heo, G. S., Luehmann, H., Zhang, Y., Saeed, M. A., Lavine, K. J., DeNardo, D. G., Pachynski, R. K., Liu, Y. & Lim, K. H., Dec 2026, In: Molecular Cancer. 25, 1, 65.Research output: Contribution to journal › Article › peer-review
Open Access -
Concurrent Procedures and Perioperative/Postoperative Care
Hill, A. L., Grierson, P., Lim, K.-H., Wilson, G., Karagkounis, G. & Fields, R., Jan 1 2025, Hepatic Arterial Infusion for Malignancy. Springer Science+Business Media, p. 79-85 7 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
-
Meeting Report From the 2024 Symposium on IRAK4 in Cancer: Highlights and Clinical Updates
Winer, E. S., Konopleva, M., Tun, H. W., Lim, K. H., Doonan, B., Metzeler, K. H., Nayak, L., Ferreri, A. J. M., von Roemeling, C., Nowakowski, G. S. & Garcia-Manero, G., Nov 2025, In: Clinical Lymphoma, Myeloma and Leukemia. 25, 11, p. e924-e932Research output: Contribution to journal › Review article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Neoadjuvant BMS-813160, Nivolumab, Gemcitabine, and Nab-Paclitaxel for Patients with Pancreatic Cancer
Grierson, P. M., Wolf, C., Suresh, R., Wang-Gillam, A., Tan, B. R., Ratner, L., Oppelt, P., Aranha, O., Frith, A., Pedersen, K. S., Spann, J., Boice, N., Brown, A., Baer, J. M., Butka, E. G., Ahmad, F., Xu, Y., Liu, J., Denardo, D. G. & Lim, K. H., Sep 1 2025, In: Clinical Cancer Research. 31, 17, p. 3644-3651 8 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
Tailored Approaches in the Treatment of Patients with Colorectal Cancer Harboring Tropomyosin Receptor Kinase Fusion and Microsatellite Instability-High: A Case Report and Literature Review
Kim, S., Itani, M., Liu, X., Sun, L., Krysiak, K., Fox, N., Firwana, B., Al Diffalha, S., Manne, U., Seeber, A., Karl, M., Frank, M., Stubblefield, H., Pedersen, K., Lim, K. H., Abushukair, H. & Khushman, M., Jan 1 2025, In: JCO Precision Oncology. 9, e2400305.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations