Personal profile
Research interests
My focus is on developing and applying computational tools to provide insight into the origins and progression of cancer. This includes understanding the clonal architecture of tumors and how they evolve in response to therapy, with a special focus on hematologic cancers. I also study effective design and targeting of cancer immunotherapies, developing open-source software for interpreting and visualizing genomic data, and integrative analysis that translates multi-dimensional genomic data into both functional and actionable contexts.
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Collaborations and top research areas from the last five years
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Evaluation of Long-Read Genome Sequencing for Genomic Profiling of Myeloid Cancers
Abel, H. J., Mahgoub, M., Davarapalli, N., Kodgule, R., Miller, C. A., Fulton, R. S., Fronick, C., Markovic, C., Heath, S., Payton, J. E., Jacoby, M. A., Link, D. C., Walter, M. J., Duncavage, E. J., Ley, T. J. & Spencer, D. H., Dec 2025, In: Journal of Molecular Diagnostics. 27, 12, p. 1242-1254 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Monitoring clonal burden as an alternative to blast count for myelodysplastic neoplasm treatment response
Jacoby, M. A., Duncavage, E. D., Khanna, A., Chang, G. S., Nonavinkere Srivatsan, S., Miller, C. A., Gao, F., Robinson, J., Shao, J., Fulton, R. S., Fronick, C. C., O’Laughlin, M., Heath, S. E., Brendel, K., Chavez, M., DiPersio, J. F., Abboud, C. N., Stockerl-Goldstein, K., Westervelt, P. & Cashen, A. & 7 others, , Jan 2025, In: Leukemia. 39, 1, p. 166-177 12 p.Research output: Contribution to journal › Article › peer-review
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Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression
Kramer, M. H., Richardson, S. N., Li, Y., Yin, T., Helton, N. M., George, D. R., Cai, M., Ramakrishnan, S. M., Katerndahl, C. D. S., Miller, C. A. & Ley, T. J., Nov 3 2025, In: Journal of Clinical Investigation. 135, 21, p. 1-17 17 p., e195929.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Molecular responses in decitabine-and decitabine/venetoclax-Treated patients with acute myeloid leukemia and myelodysplastic syndromes
Gruszczynska, A., Maiti, A., Miller, C. A., Ramakrishnan, S. M., Link, D. C., Uy, G. L., Petti, A. A., Hayes, K., Nardo, C. D. D., Ravandi, F., Ley, T. J., Spencer, D. H., Gao, F., Konopleva, M. Y. & Welch, J. S., 2024, In: Haematologica.Research output: Contribution to journal › Letter › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Neoantigen DNA vaccines are safe, feasible, and induce neoantigen-specific immune responses in triple-negative breast cancer patients
Zhang, X., Goedegebuure, S. P., Chen, M. Y., Mishra, R., Zhang, F., Yu, Y. Y., Singhal, K., Li, L., Gao, F., Myers, N. B., Vickery, T., Hundal, J., McLellan, M. D., Sturmoski, M. A., Kim, S. W., Chen, I., Davidson, J. T., Sankpal, N. V., Myles, S. & Suresh, R. & 13 others, , Dec 2024, In: Genome medicine. 16, 1, 131.Research output: Contribution to journal › Article › peer-review
Open Access48 Link opens in a new tab Scopus citations