Our laboratory is interested in the origins of pediatric inborn errors of immunity and immune dysregulation. We use genomic sequencing to identify genetic causes of pediatric disease and work to better understand these diseases using in vitro and in vivo models. Our discoveries have led to the identification and characterization of new pediatric diseases including STAT3 gain-of-function and TLR8 gain-of-function. We also have a special interest in study natural killer (NK) cells, innate immune lymphocytes that produce cytokines and can kill target cells. NK cells are important for the early control of viral infection and also play a role in tumor immunosurveillance.

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rheumatology, immunodeficiency, dermatomyositis, systemic lupus erythematosus

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The Cooper lab is committed to fostering a diverse and inclusive research environment for all trainees and staff. We appreciate that bringing together different voices is important for advancing science.