Megan Cooper

View Scopus Profile

Megan Cooper

Anthony R French, MD, PhD Professor of Pediatrics, Professor of Pediatrics, Division Chief - Pediatric Rheumatology, Professor of Pathology and Immunology

 https://orcid.org/0000-0002-5696-172X

    Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • 16918
      Citations
    1998 …2024

    Research activity per year

    Personal profile

    Research interests

    Our laboratory is interested in the origins of pediatric inborn errors of immunity and immune dysregulation. We use genomic sequencing to identify genetic causes of pediatric disease and work to better understand these diseases using in vitro and in vivo models. Our discoveries have led to the identification and characterization of new pediatric diseases including STAT3 gain-of-function and TLR8 gain-of-function. We also have a special interest in study natural killer (NK) cells, innate immune lymphocytes that produce cytokines and can kill target cells. NK cells are important for the early control of viral infection and also play a role in tumor immunosurveillance.

    Clinical interests

    rheumatology, immunodeficiency, dermatomyositis, systemic lupus erythematosus

    Mentoring

    The Cooper lab is committed to fostering a diverse and inclusive research environment for all trainees and staff. We appreciate that bringing together different voices is important for advancing science.

    Keywords

    • COVID-19

    Available to Mentor:

    • PhD/MSTP Students

    Fingerprint

    Dive into the research topics where Megan Cooper is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
    • 1 Similar Profiles
    View full fingerprint

    Collaborations and top research areas from the last five years

    Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
    Explore network further

    • A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice

      Toth, K. A., Schmitt, E. G., Kolicheski, A., Greenberg, Z. J., Levendosky, E., Saucier, N., Trammel, K., Oikonomou, V., Lionakis, M. S., Klechevsky, E., Kim, B. S., Schuettpelz, L. G., Saligrama, N. & Cooper, M. A., Aug 5 2024, In: Journal of Experimental Medicine. 221, 8, e20232091.

      Research output: Contribution to journal › Article › peer-review

      3 Scopus citations

    • Case report: Deep sequencing and long-read genome sequencing refine prior genetic analyses in families with apparent gonadal mosaicism in PIK3CD-related activated PI3K delta syndrome

      Orellana, H., Yan, J., Paul, A., Tokita, M., Ding, Y., Ghosh, R., Lewis, K. L., Davis, J., Jamal, L., Jodarski, C., Similuk, M., Saucier, N., Zhu, Z., Wang, Y., Wu, S., Ruggieri, J., Su, H. C., Uzel, G., Nahas, S. & Cooper, M. & 1 others, Walkiewicz, M. A., 2024, In: Frontiers in immunology. 15, 1451212.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (Genome Medicine, (2023), 15, 1, (22), 10.1186/s13073-023-01173-8)

      French COVID Cohort Study Group, CoV-Contact Cohort, COVID-STORM Clinicians, COVID Clinicians, Orchestra Working Group, Amsterdam UMC Covid-19 Biobank, NIAID-USUHS COVID Study Group, COVID Human Genetic Effort, COVID Human Genetic Effort, COVIDeF Study Group, Matuozzo, D., Talouarn, E., Marchal, A., Zhang, P., Manry, J., Seeleuthner, Y., Zhang, Y., Bolze, A., Chaldebas, M. & Milisavljevic, B. & 190 others, Gervais, A., Bastard, P., Asano, T., Bizien, L., Barzaghi, F., Abolhassani, H., Tayoun, A. A., Aiuti, A., Darazam, I. A., Allende, L. M., Alonso-Arias, R., Arias, A. A., Aytekin, G., Bergman, P., Bondesan, S., Bryceson, Y. T., Bustos, I. G., Cabrera-Marante, O., Carcel, S., Carrera, P., Casari, G., Chaïbi, K., Colobran, R., Condino-Neto, A., Covill, L. E., Delmonte, O. M., Zein, L. E., Flores, C., Gregersen, P. K., Gut, M., Haerynck, F., Halwani, R., Hancerli, S., Hammarström, L., Hatipoğlu, N., Karbuz, A., Keles, S., Kyheng, C., Leon-Lopez, R., Franco, J. L., Mansouri, D., Martinez-Picado, J., Akcan, O. M., Migeotte, I., Morange, P. E., Morelle, G., Martin-Nalda, A., Novelli, G., Novelli, A., Ozcelik, T., Palabiyik, F., Pan-Hammarström, Q., de Diego, R. P., Planas-Serra, L., Pleguezuelo, D. E., Prando, C., Pujol, A., Reyes, L. F., Rivière, J. G., Rodriguez-Gallego, C., Rojas, J., Rovere-Querini, P., Schlüter, A., Shahrooei, M., Sobh, A., Soler-Palacin, P., Tandjaoui-Lambiotte, Y., Tipu, I., Tresoldi, C., Troya, J., van de Beek, D., Zatz, M., Zawadzki, P., Al-Muhsen, S. Z., Alosaimi, M. F., Alsohime, F. M., Baris-Feldman, H., Butte, M. J., Constantinescu, S. N., Cooper, M. A., Dalgard, C. L., Fellay, J., Heath, J. R., Lau, Y. L., Lifton, R. P., Maniatis, T., Mogensen, T. H., von Bernuth, H., Lermine, A., Vidaud, M., Boland, A., Deleuze, J. F., Nussbaum, R., Kahn-Kirby, A., Mentre, F., Tubiana, S., Gorochov, G., Tubach, F., Hausfater, P., Meyts, I., Zhang, S. Y., Puel, A., Notarangelo, L. D., Boisson-Dupuis, S., Su, H. C., Boisson, B., Jouanguy, E., Casanova, J. L., Zhang, Q., Abel, L., Cobat, A., Al-Muhsen, S., Al-Mulla, F., Anderson, M. S., Andreakos, E., Arias, A. A., Feldman, H. B., Belot, A., Biggs, C. M., Bogunovic, D., Bondarenko, A., Bousfiha, A. A., Brodin, P., Bryceson, Y., Bustamante, C. D., Chakravorty, S., Christodoulou, J., Desai, M., Drolet, B. A., Baghdadi, J. E., Espinosa-Padilla, S., Franco, J. L., Froidure, A., Hagin, D., Henrickson, S. E., Hsieh, E. W. Y., Husebye, E., Imai, K., Itan, Y., Jarvis, E. D., Karamitros, T., Kisand, K., Ku, C. L., Ling, Y., Lucas, C. L., Maródi, L., Milner, J. D., Mironska, K., Morio, T., Ng, L. F. P., O’Farrelly, C., Okada, S., Planas, A. M., Quintana-Murci, L., Renia, L., Resnick, I., Rodríguez-Gallego, C., Sancho-Shimizu, V., Sediva, A., Seppänen, M. R. J., Shcherbina, A., Slaby, O., Snow, A. L., Soler-Palacín, P., Spaan, A. N., Tancevski, I., Tangye, S. G., Ramaswamy, S., Turvey, S. E., Uddin, F., Uddin, M. J., Vinh, D. C., Bureau, S., Vacher, Y., Gysembergh-Houal, A., Demerville, L., Chachoua, A., Abad, S., Abassi, R., Abdellaoui, A., Abdelmalek, A., Abdoul, H., Abergel, H., Abeud, F., Abgrall, S., Abisror, N., Adechian, M., Aderdour, N., Admane, H. F. & Adnet, F., Dec 2024, In: Genome medicine. 16, 1, 6.

      Research output: Contribution to journal › Comment/debate

      Open Access

    • Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoinflammatory syndrome

      Delafontaine, S., Iannuzzo, A., Bigley, T. M., Mylemans, B., Rana, R., Baatsen, P., Poli, M. C., Rymen, D., Jansen, K., Mekahli, D., Casteels, I., Cassiman, C., Demaerel, P., Lepelley, A., Frémond, M. L., Schrijvers, R., Bossuyt, X., Vints, K., Huybrechts, W. & Tacine, R. & 14 others, Willekens, K., Corveleyn, A., Boeckx, B., Baggio, M., Ehlers, L., Munck, S., Lambrechts, D., Voet, A., Moens, L., Bucciol, G., Cooper, M. A., Davis, C. M., Delon, J. & Meyts, I., Feb 15 2024, In: Journal of Clinical Investigation. 134, 4, e163604.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      5 Scopus citations

    • Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

      COVID Clinicians, GEN-COVID Study Group, COVID Human Genetic Effort, Bastard, P., Gervais, A., Taniguchi, M., Saare, L., Särekannu, K., Voyer, T. L., Philippot, Q., Rosain, J., Bizien, L., Asano, T., Garcia-Prat, M., Parra-Martínez, A., Migaud, M., Tsumura, M., Conti, F., Belot, A. & Rivière, J. G. & 183 others, Morio, T., Tanaka, J., Javouhey, E., Haerynck, F., Duvlis, S., Ozcelik, T., Keles, S., Tandjaoui-Lambiotte, Y., Escoda, S., Husain, M., Pan-Hammarström, Q., Hammarström, L., Ahlijah, G., Haidar, A. A., Soudee, C., Arseguel, V., Abolhassani, H., Sahanic, S., Tancevski, I., Nukui, Y., Hayakawa, S., Chrousos, G. P., Michos, A., Tatsi, E. B., Filippatos, F., Rodriguez-Palmero, A., Troya, J., Tipu, I., Meyts, I., Roussel, L., Ostrowski, S. R., Schidlowski, L., Prando, C., Condino-Neto, A., Cheikh, N., Bousfiha, A. A., Bakkouri, J. E., Peterson, P., Pujol, A., Lévy, R., Quartier, P., Vinh, D. C., Boisson, B., Béziat, V., Zhang, S. Y., Borghesi, A., Pession, A., Andreakos, E., Marr, N., Mentis, A. F. A., H.mogensen, T., Rodríguez-Gallego, C., Soler-Palacin, P., Colobran, R., Tillmann, V., Neven, B., Trouillet-Assant, S., Brodin, P., Abel, L., Jouanguy, E., Zhang, Q., Martinón-Torres, F., Salas, A., Gómez-Carballa, A., Gonzalez-Granado, L. I., Kisand, K., Okada, S., Puel, A., Cobat, A., Casanova, J. L., Aguilera-Albesa, S., Alkhater, S. A., Alkan, G., Castagnoli, R., Cyrus, C., Bozdemir, S. E., Emiroglu, M., Gulhan, B., Erdeniz, E. H., Hatipoglu, N., Bayhan, G. I., Jabandziev, P., Yuksek, S. K., Karbuz, A., Öz, Ş. K. T., Marseglia, G. L., Akcan, O. M., Kılıç, A. O., Parlakay, A. O., Papadaki, M., Slaba, K., Sevketoglu, E., Valencia-Ramos, J., Yahşi, A., Tuala, C., Urbieta, A. I. D., Esteban, B. D., Santalla, M. J. D., Pérez, C. F., Villaverde, J. F., Rodríguez, C. G., Allut, J. L. G., Vicente, L. G., Vázquez, E. G., Carballa, A. G., Rial, J. G., Barcala, F. J. G., Liñares, B. G., Iglesias, P. L., Massa, B. L., Fuentes, M. L., Franco, M. L., Lago, A. L., Cruz, D. N. D. L., Masid, E. N., Devesa, J. B. O., Seco, J. P., Núñez, M. P., Bernal, M. P. D. M., Freixo, H. P., Rodríguez, L. P., Pischedda, S., Romero, M. P., Reino, A. P., Hervella, G. M. P., Verdes, T. Q., Collazo, L. R., Casuso, P. R., García, S. R., Vázquez, S. R., Blanco, V. R., Calle, I. R., Velasco, C. R., Núñez, N. R., Sánchez, C. R. T., Paz, E. S., Orayyou, J. M. S., Villanueva, C. S., Fernández, S. S., Sanmartín, P. S., Muñiz, M. T., Pena, R. T., Castellano, M. T., Cuadrado, L. V., García, P. V., Iglesias, M. S. V., Lasheras, S. V., Ferreiro-Iglesias, R., Bastón-Rey, I., Calviño-Suárez, C., Aiuti, A., Al-Muhsen, S., Al-Mulla, F., Amara, A., Anderson, M. S., Arias, A. A., Arkin, L. M., Feldman, H. B., Biggs, C. M., Bogunovic, D., Bolze, A., Bondarenko, A., Bryceson, Y., Butte, M. J., Casari, G., Christodoulou, J., Constantinescu, S. N., Cooper, M. A., Dalgard, C. L., Desai, M., Drolet, B. A., Duval, X., Baghdadi, J. E., Eloy, P., Espinosa-Padilla, S., Fellay, J., Flores, C., Franco, J. L., Froidure, A., Gorochov, G., Gregersen, P. K., Grimbacher, B. & Hagin, D., Jan 1 2024, In: Journal of Experimental Medicine. 221, 2, e20231353.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      14 Scopus citations
    View all 119 Research outputs