• 7459 Citations
19992020

Research output per year

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Personal profile

Research interests

Our laboratory studies the immune response. We currently have two primary interests, mechanisms of natural killer (NK) cell activation and the regulation of the immune response in patients with autoimmune disease. NK cells are innate immune lymphocytes that are important for control of infection and we recently described that they have the capacity for immunologic memory, a function that was thought to be limited to adaptive T and B lymphocytes. These findings have clinical relevance to adoptive immunotherapy of cancers with NK cells, since pre-conditioning of cells and differentiation of memory-like NK cells may Our laboratory studies the immune response. We currently have two primary interests, mechanisms of natural killer (NK) cell activation and the regulation of the immune response in patients with autoimmune disease. NK cells are innate immune lymphocytes that are important for control of infection and we recently described that they have the capacity for immunologic memory, a function that was thought to be limited to adaptive T and B lymphocytes. These findings have clinical relevance to adoptive immunotherapy of cancers with NK cells, since pre-conditioning of cells and differentiation of memory-like NK cells may provide a beneficial anti-tumor response. The other major focus of our laboratory is the dysregulation of the immune response seen in pediatric patients with autoimmunity. Specifically, we are investigating whether somatic defects in immune cells lead to the development of autoimmunity by allowing the survival of self-reactive lymphocytes.

Areas of Clinical Interest

rheumatology, immunodeficiency, dermatomyositis, systemic lupus erythematosus

Keywords

  • COVID-19

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Research Output

ETV6 germline mutations cause HDAC3/ NCOR2 mislocalization and upregulation of interferon response genes

Fisher, M. H., Kirkpatrick, G. D., Stevens, B., Jones, C., Callaghan, M., Rajpurkar, M., Fulbright, J., Cooper, M. A., Rowley, J., Porter, C. C., Gutierrez-Hartmann, A., Jones, K., Jordan, C., Pietras, E. M. & Di Paola, J., Aug 2020, In : JCI Insight. 5, 18, e140332.

Research output: Contribution to journalArticle

Open Access
  • Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey

    Chan, A. Y., Leiding, J. W., Liu, X., Logan, B. R., Burroughs, L. M., Allenspach, E. J., Skoda-Smith, S., Uzel, G., Notarangelo, L. D., Slatter, M., Gennery, A. R., Smith, A. R., Pai, S. Y., Jordan, M. B., Marsh, R. A., Cowan, M. J., Dvorak, C. C., Craddock, J. A., Prockop, S. E., Chandrakasan, S. & 40 others, Kapoor, N., Buckley, R. H., Parikh, S., Chellapandian, D., Oshrine, B. R., Bednarski, J. J., Cooper, M. A., Shenoy, S., Davila Saldana, B. J., Forbes, L. R., Martinez, C., Haddad, E., Shyr, D. C., Chen, K., Sullivan, K. E., Heimall, J., Wright, N., Bhatia, M., Cuvelier, G. D. E., Goldman, F. D., Meyts, I., Miller, H. K., Seidel, M. G., Vander Lugt, M. T., Bacchetta, R., Weinacht, K. G., Andolina, J. R., Caywood, E., Chong, H., de la Morena, M. T., Aquino, V. M., Shereck, E., Walter, J. E., Dorsey, M. J., Seroogy, C. M., Griffith, L. M., Kohn, D. B., Puck, J. M., Pulsipher, M. A. & Torgerson, T. R., Feb 21 2020, In : Frontiers in immunology. 11, 239.

    Research output: Contribution to journalArticle

    Open Access
  • NAPDH Oxidase-Specific Flow Cytometry Allows for Rapid Genetic Triage and Classification of Novel Variants in Chronic Granulomatous Disease

    Sacco, K. A., Smith, M. J., Bahna, S. L., Buchbinder, D., Burkhardt, J., Cooper, M. A., Hartog, N. L., Kobrynski, L., Patel, K. P. & Abraham, R. S., Jan 1 2020, In : Journal of Clinical Immunology. 40, 1, p. 191-202 12 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation

    Zhao, P., Liu, I. D., Hodgin, J. B., Benke, P. I., Selva, J., Torta, F., Wenk, M. R., Endrizzi, J. A., West, O., Ou, W., Tang, E., Goh, D. L. M., Tay, S. K. H., Yap, H. K., Loh, A., Weaver, N., Sullivan, B., Larson, A., Cooper, M. A., Alhasan, K. & 7 others, Alangari, A. A., Salim, S., Gumus, E., Chen, K., Zenker, M., Hildebrandt, F. & Saba, J. D., Sep 1 2020, In : Journal of Inherited Metabolic Disease. 43, 5, p. 1131-1142 12 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Siblings with a novel MED12 variant and Odho syndrome with immune defects

    Rubin, Z., Grange, D. & Cooper, M. A., 2020, (Accepted/In press) In : Clinical Genetics.

    Research output: Contribution to journalLetter