• 564 Citations
20082020

Research output per year

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Personal profile

Research interests

The Saligrama lab is dedicated to understanding the adaptive immune responses in health and neurological disorders. Over the last few years it is becoming more and more evident that inflammation and adaptive immunity play a role in normal aging and neurological disorders. T cells are major component of the adaptive immune system and they recognize a diverse repertoire of antigens through T-cell receptors (TCRs). Major bottleneck in understanding T cell responses in health and disease is the diversity of TCRs and the vast variety of antigens that they can encounter. To circumvent these, we have taken a sequence-based approach to T cell responses and developed a robust single T cell TCR sequencing and phenotyping method and a bioinformatic analysis pipeline, which can group TCR sequences into clusters sharing specificity. Further, we have developed unbiased highthrouhput technologies to determine antigen specificity of TCRs. This is in contrast to traditional candidate approaches which involved a priori knowledge of the relevant antigens. By employing these technologies, we are exploring T cell responses at a “systems level” in varied neuroinflammatory, neurodegenerative, and neuropsychiatric disorders.

Keywords

  • COVID-19

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Research Output

  • 564 Citations
  • 20 Article
  • 1 Comment/debate

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, M. S., Middeldorp, J., Chen, K., Lehallier, B., Channappa, D., De Los Santos, M. B., McBride, A., Pluvinage, J., Elahi, F., Tam, G. K. Y., Kim, Y., Greicius, M., Wagner, A. D., Aigner, L., Galasko, D. R., Davis, M. M. & 1 others, Wyss-Coray, T., Jan 16 2020, In : Nature. 577, 7790, p. 399-404 6 p.

Research output: Contribution to journalArticle

  • 28 Scopus citations

    How Support of Early Career Researchers Can Reset Science in the Post-COVID19 World

    Gibson, E. M., Bennett, F. C., Gillespie, S. M., Güler, A. D., Gutmann, D. H., Halpern, C. H., Kucenas, S. C., Kushida, C. A., Lemieux, M., Liddelow, S., Macauley, S. L., Li, Q., Quinn, M. A., Roberts, L. W., Saligrama, N., Taylor, K. R., Venkatesh, H. S., Yalçın, B. & Zuchero, J. B., Jun 25 2020, In : Cell. 181, 7, p. 1445-1449 5 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Opposing T cell responses in experimental autoimmune encephalomyelitis

    Saligrama, N., Zhao, F., Sikora, M. J., Serratelli, W. S., Fernandes, R. A., Louis, D. M., Yao, W., Ji, X., Idoyaga, J., Mahajan, V. B., Steinmetz, L. M., Chien, Y. H., Hauser, S. L., Oksenberg, J. R., Garcia, K. C. & Davis, M. M., Aug 22 2019, In : Nature. 572, 7770, p. 481-487 7 p.

    Research output: Contribution to journalArticle

  • 24 Scopus citations

    Single-cell analysis reveals T cell infiltration in old neurogenic niches

    Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., Wyss-Coray, T., Weissman, I. L., Vogel, H., Davis, M. M. & Brunet, A., Jan 1 2019, (Accepted/In press) In : Nature.

    Research output: Contribution to journalArticle

  • 44 Scopus citations

    A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence

    Mamedov, M. R., Scholzen, A., Nair, R. V., Cumnock, K., Kenkel, J. A., Oliveira, J. H. M., Trujillo, D. L., Saligrama, N., Zhang, Y., Rubelt, F., Schneider, D. S., Chien, Y. H., Sauerwein, R. W. & Davis, M. M., Feb 20 2018, In : Immunity. 48, 2, p. 350-363.e7

    Research output: Contribution to journalArticle

    Open Access
  • 37 Scopus citations