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Research interests

The Saligrama lab is dedicated to understanding the adaptive immune responses in health and neurological disorders. Over the last few years it is becoming more and more evident that inflammation and adaptive immunity play a role in normal aging and neurological disorders. T cells are major component of the adaptive immune system and they recognize a diverse repertoire of antigens through T-cell receptors (TCRs). Major bottleneck in understanding T cell responses in health and disease is the diversity of TCRs and the vast variety of antigens that they can encounter. To circumvent these, we have taken a sequence-based approach to T cell responses and developed a robust single T cell TCR sequencing and phenotyping method and a bioinformatic analysis pipeline, which can group TCR sequences into clusters sharing specificity. Further, we have developed unbiased highthrouhput technologies to determine antigen specificity of TCRs. This is in contrast to traditional candidate approaches which involved a priori knowledge of the relevant antigens. By employing these technologies, we are exploring T cell responses at a “systems level” in varied neuroinflammatory, neurodegenerative, and neuropsychiatric disorders.

Keywords

  • COVID-19

Available to Mentor:

  • PhD/MSTP Students

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Collaborations and top research areas from the last five years

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  • Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids

    Kastenschmidt, J. M., Sureshchandra, S., Jain, A., Hernandez-Davies, J. E., de Assis, R., Wagoner, Z. W., Sorn, A. M., Mitul, M. T., Benchorin, A. I., Levendosky, E., Ahuja, G., Zhong, Q., Trask, D., Boeckmann, J., Nakajima, R., Jasinskas, A., Saligrama, N., Davies, D. H. & Wagar, L. E., Aug 8 2023, In: Immunity. 56, 8, p. 1910-1926.e7

    Research output: Contribution to journalArticlepeer-review

    Open Access
    7 Scopus citations
  • KIR+CD8+ T cells suppress pathogenic T cells and ar active in autoimmune diseases and COVID-19

    Li, J., Zaslavsky, M., Su, Y., Guo, J., Sikora, M. J., van Unen, V., Christophersen, A., Chiou, S. H., Chen, L., Li, J., Ji, X., Wilhelmy, J., McSween, A. M., Palanski, B. A., Mallajosyula, V. V. A., Bracey, N. A., Dhondalay, G. K. R., Bhamidipati, K., Pai, J., Kipp, L. B., & 16 othersDunn, J. E., Hauser, S. L., Oksenberg, J. R., Satpathy, A. T., Robinson, W. H., Dekker, C. L., Steinmetz, L. M., Khosla, C., Utz, P. J., Sollid, L. M., Chien, Y. H., Heath, J. R., Fernandez-Becker, N. Q., Nadeau, K. C., Saligrama, N. & Davis, M. M., Apr 15 2022, In: Science. 376, 6590, eabi9591.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    84 Scopus citations
  • Evolution of cytomegalovirus-responsive T cell clonality following solid organ transplantation

    Higdon, L. E., Schaffert, S., Huang, H., Montez-Rath, M. E., Lucia, M., Jha, A., Saligrama, N., Margulies, K. B., Martinez, O. M., Davis, M. M., Khatri, P. & Maltzman, J. S., Oct 15 2021, In: Journal of Immunology. 207, 8, p. 2077-2085 9 p.

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations
  • Functional consequences of memory inflation after solid organ transplantation

    Higdon, L. E., Schaffert, S., Cohen, R. H., Montez-Rath, M. E., Lucia, M., Saligrama, N., Margulies, K. B., Martinez, O. M., Tan, J. C., Davis, M. M., Khatri, P. & Maltzman, J. S., Oct 15 2021, In: Journal of Immunology. 207, 8, p. 2086-2095 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    2 Scopus citations
  • Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

    Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, M. S., Middeldorp, J., Chen, K., Lehallier, B., Channappa, D., De Los Santos, M. B., McBride, A., Pluvinage, J., Elahi, F., Tam, G. K. Y., Kim, Y., Greicius, M., Wagner, A. D., Aigner, L., Galasko, D. R., Davis, M. M., & 1 othersWyss-Coray, T., Jan 16 2020, In: Nature. 577, 7790, p. 399-404 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    430 Scopus citations