Research output per year
Research output per year
Personal profile
Research interests
The gut microbiota plays a pivotal role in many aspects of human health and modulates susceptibility to a wide spectrum of diseases.
Stromal cells possess a fundamental yet often underestimated role in maintaining tissue homeostasis and influencing immune responses during health and disease.
Our goal is to understand the intricate molecular mechanisms through which microbes modulate the function of stromal cells, acting as intermediaries between microbes and immunity. This comprehension offers the potential to capitalize on therapeutic interventions that target stromal cells and the microbiota.
To achieve this, we will employ comprehensive strategies like single-cell transcriptomics, spatial transcriptomics, metagenomics, and mouse/bacterial genetics to study highly controlled gnotobiotic model systems and human samples.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types
Cai, X., Cho, J. Y., Chen, L., Liu, Y., Ji, F., Salgado, K., Ge, S., Yang, D., Yu, H., Shao, J., Futreal, P. A., Sepesi, B., Gibbons, D., Chen, Y., Wang, G., Cheng, C., Wu, M., Zhang, J., Hsiao, A. & Xia, T., Apr 18 2025, In: iScience. 28, 4, 112162.Research output: Contribution to journal › Article › peer-review
Open Access12 Link opens in a new tab Scopus citations -
Gut complement system: A new frontier in microbiota-host communication and intestinal homeostasis
Tian, X., Zhang, L., Qian, X., Peng, Y., Chen, F., Bengtson, S., Wang, Z. & Wu, M., Dec 2025, In: Journal of Clinical Investigation. 135, 24, e188349.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Gut complement system: a new frontier in microbiota-host communication and intestinal homeostasis
Tian, X., Zhang, L., Qian, X., Peng, Y., Chen, F., Bengtson, S., Wang, Z. & Wu, M., Oct 1 2025, In: The Journal of clinical investigation. 135, 19Research output: Contribution to journal › Review article › peer-review
Open Access6 Link opens in a new tab Scopus citations -
Human gut bacteria produce structurally related monoglycolipids with contrasting immune functions
Yoo, J. S., Jung, D. J., Goh, B., Heo, K., Zheng, W., Lee, C. W. C., Seo, J. I., Geva-Zatorsky, N., Wu, M., Park, S. B., Kasper, D. L. & Oh, S. F., Nov 2025, In: Nature microbiology. 10, 11, p. 2797-2807 11 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production
Bao, B., Wang, Y., Boudreau, P., Song, X., Wu, M., Chen, X., Patik, I., Tang, Y., Ouahed, J., Ringel, A., Barends, J., Wu, C., Balskus, E., Thiagarajah, J., Liu, J., Wessels, M. R., Lencer, W. I., Kasper, D. L., An, D. & Horwitz, B. H. & 1 others, , Jan 2024, In: CMGH. 18, 2, 101350.Research output: Contribution to journal › Article › peer-review
Open Access17 Link opens in a new tab Scopus citations