Zika virus vaccines: immune response, current status, and future challenges

Justin M. Richner, Michael S. Diamond

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines using different platforms, and defined mechanisms of protection. In this review, we characterize the adaptive immune response elicited by ZIKV infections and vaccines, the status of ongoing clinical trials in humans, and discuss future challenges within the field.

Original languageEnglish
Pages (from-to)130-136
Number of pages7
JournalCurrent Opinion in Immunology
Volume53
DOIs
StatePublished - Aug 2018

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