Zika virus infection in the developing mouse produces dramatically different neuropathology dependent on viral strain

Kevin K. Noguchi, Brant S. Swiney, Sasha L. Williams, Jacob N. Huffman, Katherine Lucas, Sophie H. Wang, Kayla M. Kapral, Amber Li, Krikor T. Dikranian

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Zika virus (ZIKV) infection during pregnancy has been causally linked to a constellation of neurodevelopmental deformities in the fetus resulting in a disease termed congenital Zika syndrome (CZS). Here we detail how ZIKV infection produces extensive neuropathology in the developing mouse brain and spinal cord of both sexes. Surprisingly, neuropathology differs depending on viral strain with a French Polynesian isolate producing primarily excitotoxicity and a Brazilian isolate being almost exclusively apoptotic but occurring over a prolonged period that is more likely to produce severe hypoplasia. We also show exposure can produce a characteristic pattern of infection that mirrors neuropathology and ultimately results in gross morphological deformities strikingly similar to CZS. This research provides a valuable mouse model mirroring the clinical course of disease that can be used to test potential therapies to improve treatment and gain a better understanding of the disabilities associated with CZS.

Original languageEnglish
Pages (from-to)1145-1161
Number of pages17
JournalJournal of Neuroscience
Volume40
Issue number5
DOIs
StatePublished - Jan 29 2020

Keywords

  • Apoptosis
  • Congenital Zika syndrome
  • Excitotoxicity
  • Microcephaly
  • Microencephaly
  • Zika virus

Fingerprint

Dive into the research topics of 'Zika virus infection in the developing mouse produces dramatically different neuropathology dependent on viral strain'. Together they form a unique fingerprint.

Cite this