Yin and yang of interleukin-17 in host immunity to infection

Shabaana Khader; Shibali Das

doi:10.12688/f1000research.10862.1

Yin and yang of interleukin-17 in host immunity to infection

Shabaana Khader
, Shibali Das

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens.

Original language	English
Article number	741
Journal	F1000Research
Volume	6
DOIs	https://doi.org/10.12688/f1000research.10862.1
State	Published - 2017

Keywords

Host immune response
IL-17
Pathogens

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10.12688/f1000research.10862.1

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abstract = "The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens.",

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AU - Das, Shibali

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AB - The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens.

KW - Host immune response

KW - IL-17

KW - Pathogens

UR - https://www.scopus.com/pages/publications/85024485535

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DO - 10.12688/f1000research.10862.1

M3 - Review article

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ER -

Yin and yang of interleukin-17 in host immunity to infection

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Keywords

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