Abstract
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pathology and inflammation associated with infections. In this review, we will discuss the yin-and-yang roles of IL-17 in host immunity to pathogens.
Original language | English |
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Article number | 741 |
Journal | F1000Research |
Volume | 6 |
DOIs | |
State | Published - 2017 |
Keywords
- Host immune response
- IL-17
- Pathogens