TY - JOUR
T1 - Yeast genome duplication was followed by asynchronous differentiation of duplicated genes
AU - Langkjær, Rikke B.
AU - Cliften, Paul F.
AU - Johnston, Mark
AU - Piškur, Jure
N1 - Funding Information:
Acknowledgements We thank the laboratories of C. Gaillardin and M. Bolotin-Fukuhara for providing E. coli clones containing genomic yeast DNA, which were partially sequenced by the Génolevures project. We thank K. H. Wolfe and his co-workers for sharing their manuscripts before publication. Sequencing of Candida albicans was accomplished with the support of the NIDR and the Burroughs Wellcome Fund. This work was partially supported by the Danish Research Council.
Funding Information:
Acknowledgements We thank G. Horseman and S. Gray from Cambridge Electronic Design, and P. Jays and L. Norman for technical assistance. We thank Z. Nusser, G. Tamas and J. Csicsvari for critically reading an earlier version of the manuscript, and Y. Dalezios for help with the statistics. T.K. was supported by an Erwin Schroedinger Fellowship from the Austrian Science Fund during part of this study; G.B. was supported by the National Institutes of Health.
PY - 2003/2/20
Y1 - 2003/2/20
N2 - Gene redundancy has been observed in yeast, plant and human genomes, and is thought to be a consequence of whole-genome duplications. Baker's yeast, Saccharomyces cerevisiae, contains several hundred duplicated genes. Duplication(s) could have occurred before or after a given speciation. To understand the evolution of the yeast genome, we analysed orthologues of some of these genes in several related yeast species. On the basis of the inferred phylogeny of each set of genes, we were able to deduce whether the gene duplicated and/or specialized before or after the divergence of two yeast lineages. Here we show that the gene duplications might have occurred as a single event, and that it probably took place before the Saccharomyces and Kluyveromyces lineages diverged from each other. Further evolution of each duplicated gene pair - such as specialization or differentiation of the two copies, or deletion of a single copy - has taken place independently throughout the evolution of these species.
AB - Gene redundancy has been observed in yeast, plant and human genomes, and is thought to be a consequence of whole-genome duplications. Baker's yeast, Saccharomyces cerevisiae, contains several hundred duplicated genes. Duplication(s) could have occurred before or after a given speciation. To understand the evolution of the yeast genome, we analysed orthologues of some of these genes in several related yeast species. On the basis of the inferred phylogeny of each set of genes, we were able to deduce whether the gene duplicated and/or specialized before or after the divergence of two yeast lineages. Here we show that the gene duplications might have occurred as a single event, and that it probably took place before the Saccharomyces and Kluyveromyces lineages diverged from each other. Further evolution of each duplicated gene pair - such as specialization or differentiation of the two copies, or deletion of a single copy - has taken place independently throughout the evolution of these species.
UR - http://www.scopus.com/inward/record.url?scp=0037456380&partnerID=8YFLogxK
U2 - 10.1038/nature01419
DO - 10.1038/nature01419
M3 - Article
C2 - 12594514
AN - SCOPUS:0037456380
SN - 0028-0836
VL - 421
SP - 848
EP - 852
JO - Nature
JF - Nature
IS - 6925
ER -