YAC/STS map of 9 Mb of Xq26 at 100-kb resolution, localizing 6 ESTs, 6 genes, and 32 genetic markers

Giuseppe Pilia, Sandra Macmillan, Ramaiah Nagaraja, Steven Mumm, Jean Weissenbach, David Schlessinger

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

To facilitate functional analysis of the Xq26 region, the physical map has been extended across 9 Mb with 192 YACs and markers including 90 STSs (sequence-tagged sites) and 50 hybridization probes. Six genes and six ESTs are localized. In addition, 32 markers that detect polymorphism permit an integration of physical with genetic linkage data. The localizations of eight uncloned disease genes are thereby delimited on the physical map. The data also suggest a possible gradient of recombination across the cytogenetic band, with little or no recombination reported in the centromeric 3.5-4 Mb.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalGenomics
Volume34
Issue number1
DOIs
StatePublished - May 15 1996

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