TY - JOUR
T1 - YAC/STS map of 9 Mb of Xq26 at 100-kb resolution, localizing 6 ESTs, 6 genes, and 32 genetic markers
AU - Pilia, Giuseppe
AU - Macmillan, Sandra
AU - Nagaraja, Ramaiah
AU - Mumm, Steven
AU - Weissenbach, Jean
AU - Schlessinger, David
N1 - Funding Information:
Finer cytogenetic studies on prometaphase chromosomes early on suggested that Xq26 contains differentially staining subregions and consequently differential structural features (Harnden and Klinger, 1985). This notion has been supported by studies of the cloned DNA.
PY - 1996/5/15
Y1 - 1996/5/15
N2 - To facilitate functional analysis of the Xq26 region, the physical map has been extended across 9 Mb with 192 YACs and markers including 90 STSs (sequence-tagged sites) and 50 hybridization probes. Six genes and six ESTs are localized. In addition, 32 markers that detect polymorphism permit an integration of physical with genetic linkage data. The localizations of eight uncloned disease genes are thereby delimited on the physical map. The data also suggest a possible gradient of recombination across the cytogenetic band, with little or no recombination reported in the centromeric 3.5-4 Mb.
AB - To facilitate functional analysis of the Xq26 region, the physical map has been extended across 9 Mb with 192 YACs and markers including 90 STSs (sequence-tagged sites) and 50 hybridization probes. Six genes and six ESTs are localized. In addition, 32 markers that detect polymorphism permit an integration of physical with genetic linkage data. The localizations of eight uncloned disease genes are thereby delimited on the physical map. The data also suggest a possible gradient of recombination across the cytogenetic band, with little or no recombination reported in the centromeric 3.5-4 Mb.
UR - http://www.scopus.com/inward/record.url?scp=0029896287&partnerID=8YFLogxK
U2 - 10.1006/geno.1996.0240
DO - 10.1006/geno.1996.0240
M3 - Article
C2 - 8661023
AN - SCOPUS:0029896287
SN - 0888-7543
VL - 34
SP - 55
EP - 62
JO - Genomics
JF - Genomics
IS - 1
ER -