XenoSite server: A web-available site of metabolism prediction tool

Matthew K. Matlock, Tyler B. Hughes, S. Joshua Swamidass

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Cytochrome P450 enzymes (P450s) are metabolic enzymes that process the majority of FDA-approved, small-molecule drugs. Understanding how these enzymes modify molecule structure is key to the development of safe, effective drugs. XenoSite server is an online implementation of the XenoSite, a recently published computational model for P450 metabolism. XenoSite predicts which atomic sites of a molecule - sites of metabolism (SOMs) - are modified by P450s. XenoSite server accepts input in common chemical file formats including SDF and SMILES and provides tools for visualizing the likelihood that each atomic site is a site of metabolism for a variety of important P450s, as well as a flat file download of SOM predictions.

Original languageEnglish
Pages (from-to)1136-1137
Number of pages2
JournalBioinformatics
Volume31
Issue number7
DOIs
StatePublished - Apr 1 2015

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