Abstract
Cytochrome P450 enzymes (P450s) are metabolic enzymes that process the majority of FDA-approved, small-molecule drugs. Understanding how these enzymes modify molecule structure is key to the development of safe, effective drugs. XenoSite server is an online implementation of the XenoSite, a recently published computational model for P450 metabolism. XenoSite predicts which atomic sites of a molecule - sites of metabolism (SOMs) - are modified by P450s. XenoSite server accepts input in common chemical file formats including SDF and SMILES and provides tools for visualizing the likelihood that each atomic site is a site of metabolism for a variety of important P450s, as well as a flat file download of SOM predictions.
Original language | English |
---|---|
Pages (from-to) | 1136-1137 |
Number of pages | 2 |
Journal | Bioinformatics |
Volume | 31 |
Issue number | 7 |
DOIs | |
State | Published - Apr 1 2015 |