X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content

Ramaiah Nagaraja; Sandra MacMillan; Juha Kere; Carmela Jones; Stephanie Griffin; Matthew Schmatz; Jennifer Terrell; Michael Shomaker; Christopher Jermak; Christian Hott; Mochubeloa Masisi; Steven Mumm; Anand Srivastava; Giuseppe Pilia; Terence Featherstone; Richard Mazzarella; Sheila Kesterson; Brigid McCauley; Brian Railey; Frank Burough; Volker Nowotny; Michele D'Urso; David States; Bernard Brownstein; David Schlessinger

doi:10.1101/gr.7.3.210

X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content

Ramaiah Nagaraja
, Sandra MacMillan
, Juha Kere
, Carmela Jones
, Stephanie Griffin
, Matthew Schmatz
, Jennifer Terrell
, Michael Shomaker
, Christopher Jermak
, Christian Hott
, Mochubeloa Masisi
, Steven Mumm
, Anand Srivastava
, Giuseppe Pilia
, Terence Featherstone
, Richard Mazzarella
, Sheila Kesterson
, Brigid McCauley
, Brian Railey
, Frank Burough

Volker Nowotny, Michele D'Urso, David States, Bernard Brownstein, David Schlessinger

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 (XIST) and Xq21.3 XY homology loci.

Original language	English
Pages (from-to)	210-222
Number of pages	13
Journal	Genome research
Volume	7
Issue number	3
DOIs	https://doi.org/10.1101/gr.7.3.210
State	Published - Mar 1997

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Nagaraja, R., MacMillan, S., Kere, J., Jones, C., Griffin, S., Schmatz, M., Terrell, J., Shomaker, M., Jermak, C., Hott, C., Masisi, M., Mumm, S., Srivastava, A., Pilia, G., Featherstone, T., Mazzarella, R., Kesterson, S., McCauley, B., Railey, B., ... Schlessinger, D. (1997). X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content. Genome research, 7(3), 210-222. https://doi.org/10.1101/gr.7.3.210

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title = "X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content",

abstract = "A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 (XIST) and Xq21.3 XY homology loci.",

author = "Ramaiah Nagaraja and Sandra MacMillan and Juha Kere and Carmela Jones and Stephanie Griffin and Matthew Schmatz and Jennifer Terrell and Michael Shomaker and Christopher Jermak and Christian Hott and Mochubeloa Masisi and Steven Mumm and Anand Srivastava and Giuseppe Pilia and Terence Featherstone and Richard Mazzarella and Sheila Kesterson and Brigid McCauley and Brian Railey and Frank Burough and Volker Nowotny and Michele D'Urso and David States and Bernard Brownstein and David Schlessinger",

year = "1997",

month = mar,

doi = "10.1101/gr.7.3.210",

language = "English",

volume = "7",

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journal = "Genome research",

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Nagaraja, R, MacMillan, S, Kere, J, Jones, C, Griffin, S, Schmatz, M, Terrell, J, Shomaker, M, Jermak, C, Hott, C, Masisi, M, Mumm, S, Srivastava, A, Pilia, G, Featherstone, T, Mazzarella, R, Kesterson, S, McCauley, B, Railey, B, Burough, F, Nowotny, V, D'Urso, M, States, D, Brownstein, B & Schlessinger, D 1997, 'X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content', Genome research, vol. 7, no. 3, pp. 210-222. https://doi.org/10.1101/gr.7.3.210

TY - JOUR

T1 - X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content

AU - Nagaraja, Ramaiah

AU - MacMillan, Sandra

AU - Kere, Juha

AU - Jones, Carmela

AU - Griffin, Stephanie

AU - Schmatz, Matthew

AU - Terrell, Jennifer

AU - Shomaker, Michael

AU - Jermak, Christopher

AU - Hott, Christian

AU - Masisi, Mochubeloa

AU - Mumm, Steven

AU - Srivastava, Anand

AU - Pilia, Giuseppe

AU - Featherstone, Terence

AU - Mazzarella, Richard

AU - Kesterson, Sheila

AU - McCauley, Brigid

AU - Railey, Brian

AU - Burough, Frank

AU - Nowotny, Volker

AU - D'Urso, Michele

AU - States, David

AU - Brownstein, Bernard

AU - Schlessinger, David

PY - 1997/3

Y1 - 1997/3

N2 - A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 (XIST) and Xq21.3 XY homology loci.

AB - A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 (XIST) and Xq21.3 XY homology loci.

UR - https://www.scopus.com/pages/publications/14444286943

U2 - 10.1101/gr.7.3.210

DO - 10.1101/gr.7.3.210

M3 - Article

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AN - SCOPUS:14444286943

SN - 1088-9051

VL - 7

SP - 210

EP - 222

JO - Genome research

JF - Genome research

IS - 3

ER -

X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content

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