Abstract
A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 (XIST) and Xq21.3 XY homology loci.
Original language | English |
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Pages (from-to) | 210-222 |
Number of pages | 13 |
Journal | Genome research |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1997 |