X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content

Ramaiah Nagaraja, Sandra MacMillan, Juha Kere, Carmela Jones, Stephanie Griffin, Matthew Schmatz, Jennifer Terrell, Michael Shomaker, Christopher Jermak, Christian Hott, Mochubeloa Masisi, Steven Mumm, Anand Srivastava, Giuseppe Pilia, Terence Featherstone, Richard Mazzarella, Sheila Kesterson, Brigid McCauley, Brian Railey, Frank BuroughVolker Nowotny, Michele D'Urso, David States, Bernard Brownstein, David Schlessinger

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

A YAC/STS map of the X chromosome has reached an inter-STS resolution of 75 kb. The map density is sufficient to provide YACs or other large-insert clones that are cross-validated as sequencing substrates across the chromosome. Marker density also permits estimates of regional gene content and a detailed comparison of genetic and physical map distances. Five regions are detected with relatively high G + C, correlated with gene richness; and a 17-Mb region with very low recombination is revealed between the Xq13.3 (XIST) and Xq21.3 XY homology loci.

Original languageEnglish
Pages (from-to)210-222
Number of pages13
JournalGenome research
Volume7
Issue number3
DOIs
StatePublished - Mar 1997

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    Nagaraja, R., MacMillan, S., Kere, J., Jones, C., Griffin, S., Schmatz, M., Terrell, J., Shomaker, M., Jermak, C., Hott, C., Masisi, M., Mumm, S., Srivastava, A., Pilia, G., Featherstone, T., Mazzarella, R., Kesterson, S., McCauley, B., Railey, B., ... Schlessinger, D. (1997). X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content. Genome research, 7(3), 210-222. https://doi.org/10.1101/gr.7.3.210