WormBase 2014: New views of curated biology

Todd W. Harris, Joachim Baran, Tamberlyn Bieri, Abigail Cabunoc, Juancarlos Chan, Wen J. Chen, Paul Davis, James Done, Christian Grove, Kevin Howe, Ranjana Kishore, Raymond Lee, Yuling Li, Hans Michael Muller, Cecilia Nakamura, Philip Ozersky, Michael Paulini, Daniela Raciti, Gary Schindelman, Mary Ann TuliKimberly Van Auken, Daniel Wang, Xiaodong Wang, Gary Williams, J. D. Wong, Karen Yook, Tim Schedl, Jonathan Hodgkin, Matthew Berriman, Paul Kersey, John Spieth, Lincoln Stein, Paul W. Sternberg

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

WormBase (http://www.wormbase.org/) is a highly curated resource dedicated to supporting research using the model organism Caenorhabditis elegans. With an electronic history predating the World Wide Web, WormBase contains information ranging from the sequence and phenotype of individual alleles to genome-wide studies generated using next-generation sequencing technologies. In recent years, we have expanded the contents to include data on additional nematodes of agricultural and medical significance, bringing the knowledge of C. Elegans to bear on these systems and providing support for underserved research communities. Manual curation of the primary literature remains a central focus of the WormBase project, providing users with reliable, up-to-date and highly cross-linked information. In this update, we describe efforts to organize the original atomized and highly contextualized curated data into integrated syntheses of discrete biological topics. Next, we discuss our experiences coping with the vast increase in available genome sequences made possible through next-generation sequencing platforms. Finally, we describe some of the features and tools of the new WormBase Web site that help users better find and explore data of interest.

Original languageEnglish
Pages (from-to)D789-D793
JournalNucleic acids research
Volume42
Issue numberD1
DOIs
StatePublished - Jan 1 2014

Fingerprint Dive into the research topics of 'WormBase 2014: New views of curated biology'. Together they form a unique fingerprint.

  • Cite this

    Harris, T. W., Baran, J., Bieri, T., Cabunoc, A., Chan, J., Chen, W. J., Davis, P., Done, J., Grove, C., Howe, K., Kishore, R., Lee, R., Li, Y., Muller, H. M., Nakamura, C., Ozersky, P., Paulini, M., Raciti, D., Schindelman, G., ... Sternberg, P. W. (2014). WormBase 2014: New views of curated biology. Nucleic acids research, 42(D1), D789-D793. https://doi.org/10.1093/nar/gkt1063