Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK)

WE-ROCK Investigators; Shina Menon; Kelli A. Krallman; Ayse A. Arikan; Dana Y. Fuhrman; Stephen M. Gorga; Theresa Mottes; Nicholas Ollberding; Zaccaria Ricci; Natalja L. Stanski; David T. Selewski; Danielle E. Soranno; Michael Zappitelli; Huaiyu Zang; Katja M. Gist; Emily Ahern; Ayse Akcan Arikan; Issa Alhamoud; Rashid Alobaidi; Pilar Anton-Martin; Shanthi S. Balani; Matthew Barhight; Abby Basalely; Amee M. Bigelow; Gabriella Bottari; Andrea Cappoli; Eileen A. Ciccia; Michaela Collins; Denise Colosimo; Gerard Cortina; Mihaela A. Damian; Sara De la Mata Navazo; Gabrielle DeAbreu; Akash Deep; Kathy L. Ding; Kristin J. Dolan; Sarah N. Fernandez Lafever; Ben Gelbart; Francesco Guzzi; Isabella Guzzo; Taiki Haga; Elizabeth Harvey; Denise C. Hasson; Taylor Hill-Horowitz; Haleigh Inthavong; Catherine Joseph; Ahmad Kaddourah; Aadil Kakajiwala; Aaron D. Kessel; Sarah Korn; David M. Kwiatkowski; Jasmine Lee; Laurance Lequier; Tina Madani Kia; Kenneth E. Mah; Eleonora Marinari; Susan D. Martin; Tahagod H. Mohamed; Catherine Morgan; Theresa A. Mottes; Melissa A. Muff-Luett; Siva Namachivayam; Tara M. Neumayr; Jennifer Nhan Md; Abigail O'Rourke; Nicholas J. Ollberding; Matthew G. Pinto; Dua Qutob; Valeria Raggi; Stephanie Reynaud; Zachary A. Rumlow; María J. Santiago Lozano; Emily See; Carmela Serpe; Alyssa Serratore; Ananya Shah; Weiwen V. Shih; H. Stella Shin; Cara L. Slagle; Sonia Solomon; Rachana Srivastava; Michelle C. Starr; Erin K. Stenson; Amy E. Strong; Susan A. Taylor; Sameer V. Thadani; Amanda M. Uber; Brynna Van Wyk; Tennille N. Webb; Emily E. Zangla

doi:10.1016/j.ekir.2023.05.026

Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK)

WE-ROCK Investigators, Shina Menon, Kelli A. Krallman, Ayse A. Arikan, Dana Y. Fuhrman, Stephen M. Gorga, Theresa Mottes, Nicholas Ollberding, Zaccaria Ricci, Natalja L. Stanski, David T. Selewski, Danielle E. Soranno, Michael Zappitelli, Huaiyu Zang, Katja M. Gist, Emily Ahern, Ayse Akcan Arikan, Issa Alhamoud, Rashid Alobaidi, Pilar Anton-MartinShanthi S. Balani, Matthew Barhight, Abby Basalely, Amee M. Bigelow, Gabriella Bottari, Andrea Cappoli, Eileen A. Ciccia, Michaela Collins, Denise Colosimo, Gerard Cortina, Mihaela A. Damian, Sara De la Mata Navazo, Gabrielle DeAbreu, Akash Deep, Kathy L. Ding, Kristin J. Dolan, Sarah N. Fernandez Lafever, Ben Gelbart, Francesco Guzzi, Isabella Guzzo, Taiki Haga, Elizabeth Harvey, Denise C. Hasson, Taylor Hill-Horowitz, Haleigh Inthavong, Catherine Joseph, Ahmad Kaddourah, Aadil Kakajiwala, Aaron D. Kessel, Sarah Korn, David M. Kwiatkowski, Jasmine Lee, Laurance Lequier, Tina Madani Kia, Kenneth E. Mah, Eleonora Marinari, Susan D. Martin, Tahagod H. Mohamed, Catherine Morgan, Theresa A. Mottes, Melissa A. Muff-Luett, Siva Namachivayam, Tara M. Neumayr, Jennifer Nhan Md, Abigail O'Rourke, Nicholas J. Ollberding, Matthew G. Pinto, Dua Qutob, Valeria Raggi, Stephanie Reynaud, Zachary A. Rumlow, María J. Santiago Lozano, Emily See, Carmela Serpe, Alyssa Serratore, Ananya Shah, Weiwen V. Shih, H. Stella Shin, Cara L. Slagle, Sonia Solomon, Rachana Srivastava, Michelle C. Starr, Erin K. Stenson, Amy E. Strong, Susan A. Taylor, Sameer V. Thadani, Amanda M. Uber, Brynna Van Wyk, Tennille N. Webb, Emily E. Zangla

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Introduction: Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small and single center in design. Large international studies evaluating CRRT practice and outcomes are lacking. Herein, we describe the design of a multinational collaborative. Methods: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) is an international collaborative of pediatric specialists whose mission is to improve short- and long-term outcomes of children treated with CRRT. The aims of this multicenter retrospective study are to describe the epidemiology, liberation patterns, association of fluid balance and timing of CRRT initiation, and CRRT prescription with outcomes. Results: We included children (n = 996, 0–25 years) admitted to an intensive care unit (ICU) and treated with CRRT for AKI or FO at 32 centers (in 7 countries) from 2018 to 2021. Demographics and clinical characteristics before CRRT initiation, during the first 7 days of both CRRT, and liberation were collected. Outcomes include the following: (i) major adverse kidney events at 90 days (mortality, dialysis dependence, and persistent kidney dysfunction), and (ii) functional outcomes (functional stats scale). Conclusion: The retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve our understanding of practice heterogeneity and the association of CRRT with clinical and patient-centered outcomes. This will generate preliminary data for future interventional trials in this area.

Original language	English
Pages (from-to)	1542-1552
Number of pages	11
Journal	Kidney International Reports
Volume	8
Issue number	8
DOIs	https://doi.org/10.1016/j.ekir.2023.05.026
State	Published - Aug 2023

Keywords

WE-ROCK
acute kidney injury
continuous renal replacement therapy
database
fluid overload
pediatric

Access to Document

10.1016/j.ekir.2023.05.026

Cite this

WE-ROCK Investigators, Menon, S., Krallman, K. A., Arikan, A. A., Fuhrman, D. Y., Gorga, S. M., Mottes, T., Ollberding, N., Ricci, Z., Stanski, N. L., Selewski, D. T., Soranno, D. E., Zappitelli, M., Zang, H., Gist, K. M., Ahern, E., Akcan Arikan, A., Alhamoud, I., Alobaidi, R., ... Zangla, E. E. (2023). Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK). Kidney International Reports, 8(8), 1542-1552. https://doi.org/10.1016/j.ekir.2023.05.026

@article{d2aa526f44de41328542a32681de0367,

title = "Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK)",

abstract = "Introduction: Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small and single center in design. Large international studies evaluating CRRT practice and outcomes are lacking. Herein, we describe the design of a multinational collaborative. Methods: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) is an international collaborative of pediatric specialists whose mission is to improve short- and long-term outcomes of children treated with CRRT. The aims of this multicenter retrospective study are to describe the epidemiology, liberation patterns, association of fluid balance and timing of CRRT initiation, and CRRT prescription with outcomes. Results: We included children (n = 996, 0–25 years) admitted to an intensive care unit (ICU) and treated with CRRT for AKI or FO at 32 centers (in 7 countries) from 2018 to 2021. Demographics and clinical characteristics before CRRT initiation, during the first 7 days of both CRRT, and liberation were collected. Outcomes include the following: (i) major adverse kidney events at 90 days (mortality, dialysis dependence, and persistent kidney dysfunction), and (ii) functional outcomes (functional stats scale). Conclusion: The retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve our understanding of practice heterogeneity and the association of CRRT with clinical and patient-centered outcomes. This will generate preliminary data for future interventional trials in this area.",

keywords = "WE-ROCK, acute kidney injury, continuous renal replacement therapy, database, fluid overload, pediatric",

author = "{WE-ROCK Investigators} and Shina Menon and Krallman, {Kelli A.} and Arikan, {Ayse A.} and Fuhrman, {Dana Y.} and Gorga, {Stephen M.} and Theresa Mottes and Nicholas Ollberding and Zaccaria Ricci and Stanski, {Natalja L.} and Selewski, {David T.} and Soranno, {Danielle E.} and Michael Zappitelli and Huaiyu Zang and Gist, {Katja M.} and Emily Ahern and {Akcan Arikan}, Ayse and Issa Alhamoud and Rashid Alobaidi and Pilar Anton-Martin and Balani, {Shanthi S.} and Matthew Barhight and Abby Basalely and Bigelow, {Amee M.} and Gabriella Bottari and Andrea Cappoli and Ciccia, {Eileen A.} and Michaela Collins and Denise Colosimo and Gerard Cortina and Damian, {Mihaela A.} and {De la Mata Navazo}, Sara and Gabrielle DeAbreu and Akash Deep and Ding, {Kathy L.} and Dolan, {Kristin J.} and {Fernandez Lafever}, {Sarah N.} and Ben Gelbart and Francesco Guzzi and Isabella Guzzo and Taiki Haga and Elizabeth Harvey and Hasson, {Denise C.} and Taylor Hill-Horowitz and Haleigh Inthavong and Catherine Joseph and Ahmad Kaddourah and Aadil Kakajiwala and Kessel, {Aaron D.} and Sarah Korn and Kwiatkowski, {David M.} and Jasmine Lee and Laurance Lequier and Kia, {Tina Madani} and Mah, {Kenneth E.} and Eleonora Marinari and Martin, {Susan D.} and Mohamed, {Tahagod H.} and Catherine Morgan and Mottes, {Theresa A.} and Muff-Luett, {Melissa A.} and Siva Namachivayam and Neumayr, {Tara M.} and Md, {Jennifer Nhan} and Abigail O'Rourke and Ollberding, {Nicholas J.} and Pinto, {Matthew G.} and Dua Qutob and Valeria Raggi and Stephanie Reynaud and Rumlow, {Zachary A.} and {Santiago Lozano}, {Mar{\'i}a J.} and Emily See and Carmela Serpe and Alyssa Serratore and Ananya Shah and Shih, {Weiwen V.} and Shin, {H. Stella} and Slagle, {Cara L.} and Sonia Solomon and Rachana Srivastava and Starr, {Michelle C.} and Stenson, {Erin K.} and Strong, {Amy E.} and Taylor, {Susan A.} and Thadani, {Sameer V.} and Uber, {Amanda M.} and {Van Wyk}, Brynna and Webb, {Tennille N.} and Zangla, {Emily E.}",

note = "Publisher Copyright: {\textcopyright} 2023 International Society of Nephrology",

year = "2023",

month = aug,

doi = "10.1016/j.ekir.2023.05.026",

language = "English",

volume = "8",

pages = "1542--1552",

journal = "Kidney International Reports",

issn = "2468-0249",

number = "8",

}

WE-ROCK Investigators, Menon, S, Krallman, KA, Arikan, AA, Fuhrman, DY, Gorga, SM, Mottes, T, Ollberding, N, Ricci, Z, Stanski, NL, Selewski, DT, Soranno, DE, Zappitelli, M, Zang, H, Gist, KM, Ahern, E, Akcan Arikan, A, Alhamoud, I, Alobaidi, R, Anton-Martin, P, Balani, SS, Barhight, M, Basalely, A, Bigelow, AM, Bottari, G, Cappoli, A, Ciccia, EA, Collins, M, Colosimo, D, Cortina, G, Damian, MA, De la Mata Navazo, S, DeAbreu, G, Deep, A, Ding, KL, Dolan, KJ, Fernandez Lafever, SN, Gelbart, B, Guzzi, F, Guzzo, I, Haga, T, Harvey, E, Hasson, DC, Hill-Horowitz, T, Inthavong, H, Joseph, C, Kaddourah, A, Kakajiwala, A, Kessel, AD, Korn, S, Kwiatkowski, DM, Lee, J, Lequier, L, Kia, TM, Mah, KE, Marinari, E, Martin, SD, Mohamed, TH, Morgan, C, Mottes, TA, Muff-Luett, MA, Namachivayam, S, Neumayr, TM, Md, JN, O'Rourke, A, Ollberding, NJ, Pinto, MG, Qutob, D, Raggi, V, Reynaud, S, Rumlow, ZA, Santiago Lozano, MJ, See, E, Serpe, C, Serratore, A, Shah, A, Shih, WV, Shin, HS, Slagle, CL, Solomon, S, Srivastava, R, Starr, MC, Stenson, EK, Strong, AE, Taylor, SA, Thadani, SV, Uber, AM, Van Wyk, B, Webb, TN & Zangla, EE 2023, 'Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK)', Kidney International Reports, vol. 8, no. 8, pp. 1542-1552. https://doi.org/10.1016/j.ekir.2023.05.026

TY - JOUR

T1 - Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK)

AU - WE-ROCK Investigators

AU - Menon, Shina

AU - Krallman, Kelli A.

AU - Arikan, Ayse A.

AU - Fuhrman, Dana Y.

AU - Gorga, Stephen M.

AU - Mottes, Theresa

AU - Ollberding, Nicholas

AU - Ricci, Zaccaria

AU - Stanski, Natalja L.

AU - Selewski, David T.

AU - Soranno, Danielle E.

AU - Zappitelli, Michael

AU - Zang, Huaiyu

AU - Gist, Katja M.

AU - Ahern, Emily

AU - Akcan Arikan, Ayse

AU - Alhamoud, Issa

AU - Alobaidi, Rashid

AU - Anton-Martin, Pilar

AU - Balani, Shanthi S.

AU - Barhight, Matthew

AU - Basalely, Abby

AU - Bigelow, Amee M.

AU - Bottari, Gabriella

AU - Cappoli, Andrea

AU - Ciccia, Eileen A.

AU - Collins, Michaela

AU - Colosimo, Denise

AU - Cortina, Gerard

AU - Damian, Mihaela A.

AU - De la Mata Navazo, Sara

AU - DeAbreu, Gabrielle

AU - Deep, Akash

AU - Ding, Kathy L.

AU - Dolan, Kristin J.

AU - Fernandez Lafever, Sarah N.

AU - Gelbart, Ben

AU - Guzzi, Francesco

AU - Guzzo, Isabella

AU - Haga, Taiki

AU - Harvey, Elizabeth

AU - Hasson, Denise C.

AU - Hill-Horowitz, Taylor

AU - Inthavong, Haleigh

AU - Joseph, Catherine

AU - Kaddourah, Ahmad

AU - Kakajiwala, Aadil

AU - Kessel, Aaron D.

AU - Korn, Sarah

AU - Kwiatkowski, David M.

AU - Lee, Jasmine

AU - Lequier, Laurance

AU - Kia, Tina Madani

AU - Mah, Kenneth E.

AU - Marinari, Eleonora

AU - Martin, Susan D.

AU - Mohamed, Tahagod H.

AU - Morgan, Catherine

AU - Mottes, Theresa A.

AU - Muff-Luett, Melissa A.

AU - Namachivayam, Siva

AU - Neumayr, Tara M.

AU - Md, Jennifer Nhan

AU - O'Rourke, Abigail

AU - Ollberding, Nicholas J.

AU - Pinto, Matthew G.

AU - Qutob, Dua

AU - Raggi, Valeria

AU - Reynaud, Stephanie

AU - Rumlow, Zachary A.

AU - Santiago Lozano, María J.

AU - See, Emily

AU - Serpe, Carmela

AU - Serratore, Alyssa

AU - Shah, Ananya

AU - Shih, Weiwen V.

AU - Shin, H. Stella

AU - Slagle, Cara L.

AU - Solomon, Sonia

AU - Srivastava, Rachana

AU - Starr, Michelle C.

AU - Stenson, Erin K.

AU - Strong, Amy E.

AU - Taylor, Susan A.

AU - Thadani, Sameer V.

AU - Uber, Amanda M.

AU - Van Wyk, Brynna

AU - Webb, Tennille N.

AU - Zangla, Emily E.

PY - 2023/8

Y1 - 2023/8

N2 - Introduction: Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small and single center in design. Large international studies evaluating CRRT practice and outcomes are lacking. Herein, we describe the design of a multinational collaborative. Methods: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) is an international collaborative of pediatric specialists whose mission is to improve short- and long-term outcomes of children treated with CRRT. The aims of this multicenter retrospective study are to describe the epidemiology, liberation patterns, association of fluid balance and timing of CRRT initiation, and CRRT prescription with outcomes. Results: We included children (n = 996, 0–25 years) admitted to an intensive care unit (ICU) and treated with CRRT for AKI or FO at 32 centers (in 7 countries) from 2018 to 2021. Demographics and clinical characteristics before CRRT initiation, during the first 7 days of both CRRT, and liberation were collected. Outcomes include the following: (i) major adverse kidney events at 90 days (mortality, dialysis dependence, and persistent kidney dysfunction), and (ii) functional outcomes (functional stats scale). Conclusion: The retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve our understanding of practice heterogeneity and the association of CRRT with clinical and patient-centered outcomes. This will generate preliminary data for future interventional trials in this area.

AB - Introduction: Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small and single center in design. Large international studies evaluating CRRT practice and outcomes are lacking. Herein, we describe the design of a multinational collaborative. Methods: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) is an international collaborative of pediatric specialists whose mission is to improve short- and long-term outcomes of children treated with CRRT. The aims of this multicenter retrospective study are to describe the epidemiology, liberation patterns, association of fluid balance and timing of CRRT initiation, and CRRT prescription with outcomes. Results: We included children (n = 996, 0–25 years) admitted to an intensive care unit (ICU) and treated with CRRT for AKI or FO at 32 centers (in 7 countries) from 2018 to 2021. Demographics and clinical characteristics before CRRT initiation, during the first 7 days of both CRRT, and liberation were collected. Outcomes include the following: (i) major adverse kidney events at 90 days (mortality, dialysis dependence, and persistent kidney dysfunction), and (ii) functional outcomes (functional stats scale). Conclusion: The retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve our understanding of practice heterogeneity and the association of CRRT with clinical and patient-centered outcomes. This will generate preliminary data for future interventional trials in this area.

KW - WE-ROCK

KW - acute kidney injury

KW - continuous renal replacement therapy

KW - database

KW - fluid overload

KW - pediatric

UR - http://www.scopus.com/inward/record.url?scp=85163882254&partnerID=8YFLogxK

U2 - 10.1016/j.ekir.2023.05.026

DO - 10.1016/j.ekir.2023.05.026

M3 - Article

C2 - 37547524

AN - SCOPUS:85163882254

SN - 2468-0249

VL - 8

SP - 1542

EP - 1552

JO - Kidney International Reports

JF - Kidney International Reports

IS - 8

ER -

Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK)

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this