TY - JOUR
T1 - Work characteristics and incidence of type 2 diabetes in women
AU - Kroenke, Candyce H.
AU - Spiegelman, Donna
AU - Manson, Jo Ann
AU - Schernhammer, Eva S.
AU - Colditz, Graham A.
AU - Kawachi, Ichiro
N1 - Funding Information:
This research was supported by grant CA87969 supplied by the National Cancer Institute, National Institutes of Health, Bethesda, Maryland, and by the Robert Wood Johnson Foundation. C. H. K. is a Robert Wood Johnson Health and Society Scholar at the University of California in San Francisco and Berkeley, California.
PY - 2007/1
Y1 - 2007/1
N2 - The authors prospectively investigated associations between potentially stressful work characteristics and type 2 diabetes incidence in 62,574 young and middle-aged women, aged 29-46 years at baseline in 1993, from the Nurses' Health Study II; 365 cases of type 2 diabetes accrued over 6 years of follow-up. Cox proportional hazards regression was used to simultaneously evaluate associations of hours per week in paid employment, years of rotating night-shift work, and job strain with incidence of type 2 diabetes. In multivariate- adjusted analyses, women working less than 20 hours per week had a lower risk of diabetes (relative risk = 0.80, 95% confidence interval: 0.50, 1.30), and those working overtime (≥41 hours/week) had an elevated risk of diabetes (relative risk = 1.23, 95% confidence interval: 0.98, 1.55) compared with women working 21-40 hours/week (referent) in paid employment (ptrend = 0.03). In subsequent analysis, the elevated association appeared stronger in unmarried women (pinteraction = 0.02). A positive association between years in rotating night-shift work and diabetes was mediated entirely by body weight. Job strain was unrelated to risk of type 2 diabetes. In conclusion, working overtime predicted a slightly elevated risk of type 2 diabetes in young and middle-aged female nurses.
AB - The authors prospectively investigated associations between potentially stressful work characteristics and type 2 diabetes incidence in 62,574 young and middle-aged women, aged 29-46 years at baseline in 1993, from the Nurses' Health Study II; 365 cases of type 2 diabetes accrued over 6 years of follow-up. Cox proportional hazards regression was used to simultaneously evaluate associations of hours per week in paid employment, years of rotating night-shift work, and job strain with incidence of type 2 diabetes. In multivariate- adjusted analyses, women working less than 20 hours per week had a lower risk of diabetes (relative risk = 0.80, 95% confidence interval: 0.50, 1.30), and those working overtime (≥41 hours/week) had an elevated risk of diabetes (relative risk = 1.23, 95% confidence interval: 0.98, 1.55) compared with women working 21-40 hours/week (referent) in paid employment (ptrend = 0.03). In subsequent analysis, the elevated association appeared stronger in unmarried women (pinteraction = 0.02). A positive association between years in rotating night-shift work and diabetes was mediated entirely by body weight. Job strain was unrelated to risk of type 2 diabetes. In conclusion, working overtime predicted a slightly elevated risk of type 2 diabetes in young and middle-aged female nurses.
KW - Diabetes mellitus, type 2
KW - Nursing staff
KW - Stress, psychological
KW - Women
KW - Work schedule tolerance
UR - http://www.scopus.com/inward/record.url?scp=33846256311&partnerID=8YFLogxK
U2 - 10.1093/aje/kwj355
DO - 10.1093/aje/kwj355
M3 - Article
C2 - 17071844
AN - SCOPUS:33846256311
VL - 165
SP - 175
EP - 183
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 2
ER -