TY - JOUR
T1 - Word retrieval learning modulates right frontal cortex in patients with left frontal damage
AU - Blasi, Valeria
AU - Young, Alexis C.
AU - Tansy, Aaron P.
AU - Petersen, Steven E.
AU - Snyder, Abraham Z.
AU - Corbetta, Maurizio
N1 - Funding Information:
This work was supported by grants from National Institute of Neurological Disorders (NS06833), the J.S. McDonnell Foundation, and the Mallinkrodt Institute of Radiology to M.C. We thank Drs. Conturo, Akbudak, Ollinger, and McAvoy for fMRI development and methodology; Dr. Nina Dronkers for comments on an earlier version of the manuscript; and the Alzheimer Disease Research Center at Washington University for referral of some control subjects.
PY - 2002/9/26
Y1 - 2002/9/26
N2 - Previous studies have suggested that recovery or compensation of language function after a lesion in the left hemisphere may depend on mechanisms in the right hemisphere. However, a direct relationship between performance and right hemisphere activity has not been established. Here, we show that patients with left frontal lesions and partially recovered aphasia learn, at a normal rate, a novel word retrieval task that requires the damaged cortex. Verbal learning is accompanied by specific response decrements in right frontal and right occipital cortex, strongly supporting the compensatory role of the right hemisphere. Furthermore, responses in left occipital cortex are abnormal and not modulated by practice. These findings indicate that frontal cortex is a source of top-down signals during learning.
AB - Previous studies have suggested that recovery or compensation of language function after a lesion in the left hemisphere may depend on mechanisms in the right hemisphere. However, a direct relationship between performance and right hemisphere activity has not been established. Here, we show that patients with left frontal lesions and partially recovered aphasia learn, at a normal rate, a novel word retrieval task that requires the damaged cortex. Verbal learning is accompanied by specific response decrements in right frontal and right occipital cortex, strongly supporting the compensatory role of the right hemisphere. Furthermore, responses in left occipital cortex are abnormal and not modulated by practice. These findings indicate that frontal cortex is a source of top-down signals during learning.
UR - http://www.scopus.com/inward/record.url?scp=0037179827&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(02)00936-4
DO - 10.1016/S0896-6273(02)00936-4
M3 - Article
C2 - 12367514
AN - SCOPUS:0037179827
SN - 0896-6273
VL - 36
SP - 159
EP - 170
JO - Neuron
JF - Neuron
IS - 1
ER -