Abstract

The evolutionary conserved Wnt signaling transduction pathway plays essential roles in a wide array of biologic processes including embryonic development, branching morphogenesis, proliferation and carcinogenesis. Over the past ten years it has become increasingly clear that Wnt signaling also regulates the response of adult organs to disease processes, including kidney disease. This review will focus on the growing literature implicating important roles for Wnt signaling during disease in two separate kidney compartments: the tubular epithelium and the interstitium.

Original languageEnglish
Pages (from-to)163-171
Number of pages9
JournalHistology and Histopathology
Volume30
Issue number2
StatePublished - 2015

Keywords

  • Fibrosis
  • Kidny injury
  • Myofobroblast
  • Wnt
  • β-catenin

Fingerprint

Dive into the research topics of 'Wnt signaling in kidney tubulointerstitium during disease'. Together they form a unique fingerprint.

Cite this