Wnt signaling in kidney tubulointerstitium during disease

Omar H. Maarouf, Yoichiro Ikeda, Benjamin D. Humphreys

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

The evolutionary conserved Wnt signaling transduction pathway plays essential roles in a wide array of biologic processes including embryonic development, branching morphogenesis, proliferation and carcinogenesis. Over the past ten years it has become increasingly clear that Wnt signaling also regulates the response of adult organs to disease processes, including kidney disease. This review will focus on the growing literature implicating important roles for Wnt signaling during disease in two separate kidney compartments: the tubular epithelium and the interstitium.

Original languageEnglish
Pages (from-to)163-171
Number of pages9
JournalHistology and Histopathology
Volume30
Issue number2
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Fibrosis
  • Kidny injury
  • Myofobroblast
  • Wnt
  • β-catenin

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