@article{98d69f7871004844919b79f2340190f7,
title = "WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop",
abstract = "WNT signal transduction is essential for normal development and contributes to many human diseases. Agajanian et al. used a kinase gain-of-function screen to show that WNT activates the AAK1 kinase to promote clathrin-mediated endocytosis of the WNT receptor. This work identifies an AAK-driven negative feedback loop that downregulates WNT signaling.",
keywords = "AAK1, AP2M1, LRP6, WNT signaling, clathrin, endocytosis, feedback loop, gain-of-function screen, kinase",
author = "Agajanian, {Megan J.} and Walker, {Matthew P.} and Axtman, {Alison D.} and Ruela-de-Sousa, {Roberta R.} and Serafin, {D. Stephen} and Rabinowitz, {Alex D.} and Graham, {David M.} and Ryan, {Meagan B.} and Tigist Tamir and Yuko Nakamichi and Gammons, {Melissa V.} and Bennett, {James M.} and Cou{\~n}ago, {Rafael M.} and Drewry, {David H.} and Elkins, {Jonathan M.} and Carina Gileadi and Opher Gileadi and Godoi, {Paulo H.} and Nirav Kapadia and Susanne M{\"u}ller and Santiago, {Andr{\'e} S.} and Sorrell, {Fiona J.} and Wells, {Carrow I.} and Oleg Fedorov and Willson, {Timothy M.} and Zuercher, {William J.} and Major, {Michael B.}",
note = "Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2019",
month = jan,
day = "2",
doi = "10.1016/j.celrep.2018.12.023",
language = "English",
volume = "26",
pages = "79--93.e8",
journal = "Cell Reports",
issn = "2639-1856",
number = "1",
}