Abstract
Summary: Acute kidney injury (AKI) portends a poor clinical prognosis and increases the risk for the development of chronic kidney disease (CKD). Currently, there are no therapies to treat AKI or prevent its progression to CKD. Wnt/β-catenin is a critical regulator of kidney development that is up-regulated after injury. Most of the literature support a beneficial role for Wnt/β-catenin in AKI, but suggest that this pathway promotes the progression of tubulointerstitial fibrosis, the hallmark of CKD progression. We review the role of Wnt/β-catenin in renal injury with a focus on its potential as a therapeutic target in AKI and in AKI to CKD transition.
Original language | English |
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Pages (from-to) | 126-137 |
Number of pages | 12 |
Journal | Seminars in Nephrology |
Volume | 40 |
Issue number | 2 |
DOIs | |
State | Published - Mar 2020 |
Keywords
- Acute kidney injury
- chronic kidney disease
- β-catenin