Russo and DiAntonio identify a dysregulated MAPK signaling pathway in the fly model of fragile X syndrome. MAP3K Wnd/DLK drives dFmr1 mutant phenotypes, and pharmacological inhibition of Wnd/DLK prevents neural dysfunction in this model, thus highlighting a possible role for Wnd/DLK in the pathophysiology of fragile X syndrome.

Original languageEnglish
Pages (from-to)2581-2593.e5
JournalCell Reports
Issue number10
StatePublished - Sep 3 2019


  • GNE-3511
  • JNK
  • grooming behavior
  • highwire
  • neurodegeneration
  • neurodevelopment
  • neuromuscular junction
  • synaptic transmission


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