@article{5a21a6c013624e44807d2fcf8bede46f,
title = "Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome",
abstract = "Russo and DiAntonio identify a dysregulated MAPK signaling pathway in the fly model of fragile X syndrome. MAP3K Wnd/DLK drives dFmr1 mutant phenotypes, and pharmacological inhibition of Wnd/DLK prevents neural dysfunction in this model, thus highlighting a possible role for Wnd/DLK in the pathophysiology of fragile X syndrome.",
keywords = "GNE-3511, JNK, grooming behavior, highwire, neurodegeneration, neurodevelopment, neuromuscular junction, synaptic transmission",
author = "Alexandra Russo and Aaron DiAntonio",
note = "Funding Information: This work was supported by funding from the NIH grants R01 NS065053 and R01 CA219866 to A.D. and NIH F31 NS101827 to A.R. We thank Thomas Jongens for sharing dFmr1 flies. We thank Joe Dougherty and the Dougherty lab for technical advice and assistance. We also thank Jeff Milbrandt and the Milbrandt lab for helpful discussions. Lastly, we are grateful to all members of the DiAntonio Lab for fruitful scientific discussions and support. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = sep,
day = "3",
doi = "10.1016/j.celrep.2019.08.001",
language = "English",
volume = "28",
pages = "2581--2593.e5",
journal = "Cell Reports",
issn = "2211-1247",
number = "10",
}