Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy

Jahyun Koo, Matthew R. MacEwan, Seung Kyun Kang, Sang Min Won, Manu Stephen, Paul Gamble, Zhaoqian Xie, Ying Yan, Yu Yu Chen, Jiho Shin, Nathan Birenbaum, Sangjin Chung, Sung Bong Kim, Jawad Khalifeh, Daniel V. Harburg, Kelsey Bean, Michael Paskett, Jeonghyun Kim, Zohny S. Zohny, Seung Min LeeRuoyao Zhang, Kaijing Luo, Bowen Ji, Anthony Banks, Hyuck Mo Lee, Younggang Huang, Wilson Z. Ray, John A. Rogers

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Peripheral nerve injuries represent a significant problem in public health, constituting 2–5% of all trauma cases1. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function2. Numerous studies report the potential of pharmacological approaches (for example, growth factors, immunosuppressants) to accelerate and enhance nerve regeneration in rodent models3–10. Unfortunately, few have had a positive impact in clinical practice. Direct intraoperative electrical stimulation of injured nerve tissue proximal to the site of repair has been demonstrated to enhance and accelerate functional recovery11,12, suggesting a novel nonpharmacological, bioelectric form of therapy that could complement existing surgical approaches. A significant limitation of this technique is that existing protocols are constrained to intraoperative use and limited therapeutic benefits13. Herein we introduce (i) a platform for wireless, programmable electrical peripheral nerve stimulation, built with a collection of circuit elements and substrates that are entirely bioresorbable and biocompatible, and (ii) the first reported demonstration of enhanced neuroregeneration and functional recovery in rodent models as a result of multiple episodes of electrical stimulation of injured nervous tissue.

Original languageEnglish
Pages (from-to)1830-1836
Number of pages7
JournalNature medicine
Volume24
Issue number12
DOIs
StatePublished - Dec 1 2018

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    Koo, J., MacEwan, M. R., Kang, S. K., Won, S. M., Stephen, M., Gamble, P., Xie, Z., Yan, Y., Chen, Y. Y., Shin, J., Birenbaum, N., Chung, S., Kim, S. B., Khalifeh, J., Harburg, D. V., Bean, K., Paskett, M., Kim, J., Zohny, Z. S., ... Rogers, J. A. (2018). Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy. Nature medicine, 24(12), 1830-1836. https://doi.org/10.1038/s41591-018-0196-2