TY - JOUR
T1 - Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry
AU - Zhang, Hao
AU - Gutruf, Philipp
AU - Meacham, Kathleen
AU - Montana, Michael C.
AU - Zhao, Xingyue
AU - Chiarelli, Antonio M.
AU - Vázquez-Guardado, Abraham
AU - Norris, Aaron
AU - Lu, Luyao
AU - Guo, Qinglei
AU - Xu, Chenkai
AU - Wu, Yixin
AU - Zhao, Hangbo
AU - Ning, Xin
AU - Bai, Wubin
AU - Kandela, Irawati
AU - Haney, Chad R.
AU - Chanda, Debashis
AU - Gereau, Robert W.
AU - Rogers, John A.
N1 - Publisher Copyright:
Copyright © 2019 The Authors, some rights reserved.
PY - 2019
Y1 - 2019
N2 - Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O 2 -mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O 2 -mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.
AB - Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O 2 -mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O 2 -mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.
UR - https://www.scopus.com/pages/publications/85062998912
U2 - 10.1126/sciadv.aaw0873
DO - 10.1126/sciadv.aaw0873
M3 - Article
C2 - 30873435
AN - SCOPUS:85062998912
SN - 2375-2548
VL - 5
JO - Science Advances
JF - Science Advances
IS - 3
M1 - eaaw0873
ER -