Widely Metastatic Choroid Plexus Carcinoma Associated with Novel TP53 Somatic Mutation

Brandon S. Baksh, Namita Sinha, Afshin Salehi, Rowland H. Han, Brandon A. Miller, Sonika Dahiya, Karen M. Gauvain, David D. Limbrick

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Choroid plexus carcinoma (CPC) is a rare, malignant tumor occurring more commonly in children than adults. This case report describes the clinical course of a 3-year-old boy with a rare case of metastatic CPC with a novel TP53 mutation. Case Description: A 3-year-old boy presented with postconcussive symptoms after a fall. Computed tomography and magnetic resonance imaging revealed lesions in the suprasellar cistern, left lateral ventricle, and cauda equina. The tumor was diagnosed as choroid plexus carcinoma with a novel TP53 V216M somatic mutation. The patient underwent resection of the left lateral ventricle lesion. Conclusion: We describe a case of CPC with highly metastatic characteristics and a novel TP53 mutation. Our report implicates TP53 in the pathogenesis of pediatric CPC, and we emphasize that CPC in children should prompt careful consideration of TP53 status to inform prognosis and clinical treatment.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalWorld neurosurgery
Volume119
DOIs
StatePublished - Nov 2018

Keywords

  • Choroid plexus carcinoma
  • Metastatic
  • Pediatric brain tumor
  • TP53

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