Mitochondrial uncoupling protein 1 (UCP1) is a key regulator of adaptive thermogenesis and energy expenditure. Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature. In this issue of Cell Metabolism, Feldmann et al. (2009) unmask an obesogenic phenotype by simply maintaining these mice at thermoneutrality.

Original languageEnglish
Pages (from-to)111-112
Number of pages2
JournalCell metabolism
Issue number2
StatePublished - Feb 4 2009


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