TY - JOUR
T1 - Why does obesity cause diabetes?
AU - Klein, Samuel
AU - Gastaldelli, Amalia
AU - Yki-Järvinen, Hannele
AU - Scherer, Philipp E.
N1 - Funding Information:
The study was supported by National Institutes of Health grants DK56341 (Nutrition Obesity Research Center), DK20579 (Diabetes Research Center), UL1TR002345 (Clinical and Translational Science Award), RC2-DK118620, R01-DK55758 and R01-DK099110, the Academy of Finland, and support from Merck, Novo Nordisk, and the Sigrid Jusélius Foundation. S.K. serves as a scientific consultant for Janssen and Altimmune and has a sponsored research agreement with Janssen. A.G. serves as a scientific consultant for Eli Lilly, Gilead, Inventiva, and Boehringer. H.Y.-J. serves as a scientific consultant for Merck, Novo Nordisk, Eli Lilly, and Hamni Pharmaceuticals. P.E.S. has sponsored research agreements with Merck and Novo Nordisk.
Funding Information:
The study was supported by National Institutes of Health grants DK56341 ( Nutrition Obesity Research Center ), DK20579 ( Diabetes Research Center ), UL1TR002345 ( Clinical and Translational Science Award ), RC2-DK118620 , R01-DK55758 and R01-DK099110 , the Academy of Finland , and support from Merck , Novo Nordisk , and the Sigrid Jusélius Foundation .
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/1/4
Y1 - 2022/1/4
N2 - The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.
AB - The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.
UR - http://www.scopus.com/inward/record.url?scp=85121919968&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2021.12.012
DO - 10.1016/j.cmet.2021.12.012
M3 - Review article
C2 - 34986330
AN - SCOPUS:85121919968
SN - 1550-4131
VL - 34
SP - 11
EP - 20
JO - Cell Metabolism
JF - Cell Metabolism
IS - 1
ER -