Why do hemophiliacs bleed?

G. J. Broze

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


A revised hypothesis of coagulation integrates all the factors known to be involved into a single pathway that is initiated by factor VIIa/tissue factor and in which 'contact' factors are not required. A key point is that the initial hemostatic response must be 'consolidated' by the progressive local generation of factor Xa and thrombin.

Original languageEnglish
Pages (from-to)71-74+79
JournalHospital Practice
Issue number3
StatePublished - Jan 1 1992


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