Why do epidemiologic studies find an inverse association between intraprostatic inflammation and prostate cancer: A possible role for colliding bias?

Marvin E. Langston, Karen S. Sfanos, Saira Khan, Trang Q. Nguyen, Angelo M. de Marzo, Elizabeth A. Platz, Siobhan Sutcliffe

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Inflammation is an emerging risk factor for prostate cancer based largely on evidence from animal models and histopathologic observations. However, findings from patho-epidemiologic studies of intraprostatic inflammation and prostate cancer have been less supportive, with inverse associations observed in many studies of intraprostatic inflammation and prostate cancer diagnosis. Here, we propose collider stratification bias as a potential methodologic explanation for these inverse findings and provide strategies for conducting future etiologic studies of intraprostatic inflammation and prostate cancer.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume30
Issue number2
DOIs
StatePublished - Feb 2021

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