Whole-exome sequencing and an iPSC-derived cardiomyocyte model provides a powerful platform for gene discovery in left ventricular hypertrophy

Keyphrases

• Induced Pluripotent Stem Cells (iPSCs) 100%
• Whole Exome Sequencing 100%
• Gene Discovery 100%
• Left Ventricular Hypertrophy 100%
• Cardiomyocyte Model 100%
• LV Mass 66%
• THBS1 50%
• Hypertrophy 33%
• Missense mutation 33%
• Nonsense mutation 33%
• Combining Evidence 33%
• RNA Sequencing (RNA-seq) 16%
• Gene Expression 16%
• Cardiovascular Disease 16%
• African American 16%
• Glycoprotein 16%
• Cell-derived 16%
• Sequence Reads 16%
• Missense Variants 16%
• HLA-B 16%
• Cardiomyocytes 16%
• People of Color 16%
• Pressure Overload 16%
• Exon 13 16%
• Target Capture 16%
• Sex Body 16%
• Genetic Predictors 16%
• Familial Relationships 16%
• Risk Loci 16%
• MRNA-seq 16%
• Linear Mixed Model 16%
• Differentially Expressed 16%
• Human-induced 16%
• Association Test 16%
• Gene Expression Differences 16%
• Nonsense Variant 16%
• Average Coverage 16%
• Weight Relationship 16%
• MTSS1 16%
• Illumina MiSeq 16%
• Capture Region 16%
• Regional Linkages 16%

Medicine and Dentistry

• Cardiac Muscle Cell 100%
• Left Ventricular Hypertrophy 100%
• Exome Sequencing 100%
• Gene Discovery 100%
• Induced Pluripotent Stem Cell 100%
• Gene Expression 33%
• Missense Mutation 33%
• Nonsense Mutation 33%
• RNA Sequencing 16%
• Exon 16%
• Cardiovascular Disease 16%
• Adhesive Agent 16%
• Gene Linkage 16%
• Body Weight 16%
• Glycoprotein 16%
• Mixed Model 16%
• Messenger RNA 16%

Biochemistry, Genetics and Molecular Biology

• Induced Pluripotent Stem Cell 100%
• Exome Sequencing 100%
• Gene Discovery 100%
• Cardiac Muscle Cell 100%
• Candidate Gene 50%
• Gene Expression 33%
• Genetics 33%
• Missense Mutation 33%
• Nonsense Mutation 33%
• Exon 16%
• Glycoprotein 16%
• Body Weight 16%
• Missense 16%
• Gene Linkage 16%
• RNA Sequencing 16%
• HLA-B 16%
• Messenger RNA 16%