WHO global research priorities for antimicrobial resistance in human health

WHO Research Agenda for AMR in Human Health Collaborators

doi:10.1016/S2666-5247(24)00134-4

WHO global research priorities for antimicrobial resistance in human health

WHO Research Agenda for AMR in Human Health Collaborators

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Abstract

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

Original language	English
Article number	100902
Journal	The Lancet Microbe
Volume	5
Issue number	11
DOIs	https://doi.org/10.1016/S2666-5247(24)00134-4
State	Published - Nov 2024

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10.1016/S2666-5247(24)00134-4

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@article{6f08be914765494fb9214a5c2d127cea,

title = "WHO global research priorities for antimicrobial resistance in human health",

abstract = "The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.",

author = "\{WHO Research Agenda for AMR in Human Health Collaborators\} and Silvia Bertagnolio and Zlatina Dobreva and Centner, \{Chad M.\} and Olaru, \{Ioana Diana\} and Daniele Don{\`a} and Stefano Burzo and Huttner, \{Benedikt D.\} and Antoine Chaillon and Nebiat Gebreselassie and Teodora Wi and Mateusz Hasso-Agopsowicz and Benedetta Allegranzi and Hatim Sati and Verica Ivanovska and Kothari, \{Kavita U.\} and Balkhy, \{Hanan H.\} and Alessandro Cassini and Hamers, \{Raph L.\} and Weezenbeek, \{Kitty Van\} and David Aanensen and Alexandre Alanio and Ana Alastruey-Izquierdo and Tinsae Alemayehu and Majdi Al-Hasan and Karel Allegaert and Al-Maani, \{Amal Saif\} and Jameela Al-Salman and Alshukairi, \{Abeer Nizar\} and Afreenish Amir and Tanya Applegate and Araj, \{George F.\} and Villalobos, \{Marlen Arce\} and Christine {\AA}rdal and Diane Ashiru-Oredope and Ashley, \{Elizabeth A.\} and Babin, \{Fran{\c c}ois Xavier\} and Bachmann, \{Laura H.\} and Till Bachmann and Baker, \{Kate Susan\} and Manica Balasegaram and Colleen Bamford and Fernando Baquero and Barcelona, \{Laura Isabel\} and Quique Bassat and Matteo Bassetti and Sulagna Basu and Justin Beardsley and V{\'a}squez, \{Grey Benoit\} and Berkley, \{James A.\} and Bhatnagar, \{Anuj K.\} and Julia Bielicki and Julie Bines and Felix Bongomin and Bonomo, \{Robert A.\} and Bradley, \{John S.\} and Catriona Bradshaw and Ana Brett and Adrian Brink and Colin Brown and Jeremy Brown and Kirsty Buising and Carolee Carson and Carvalho, \{Anna Cristina\} and Elio Castagnola and Marco Cavaleri and Michele Cecchini and Chishala Chabala and Chaisson, \{Richard E.\} and Arunaloke Chakrabarti and Clare Chandler and Chandy, \{Sujith John\} and Esmita Charani and Lisa Chen and Francesca Chiara and Anuradha Chowdhary and Arlene Chua and Pem Chuki and Chun, \{Doo Ryeon\} and Gavin Churchyard and Daniela Cirillo and Lauren Clack and Coffin, \{Susan E.\} and Jennifer Cohn and Michelle Cole and John Conly and Ben Cooper and Alejandra Corso and Cosgrove, \{Sara E.\} and Helen Cox and Daley, \{Charles L.\} and Saffiatou Darboe and Tom Darton and Gerry Davies and \{de Egea\}, Viviana and Amela Dedei{\'c}-Ljubovi{\'c} and Miranda Deeves and Claudia Denkinger and Dillon, \{Jo Anne R.\} and Angela Dramowski and Brian Eley and \{Roberta Esposito\}, \{Susanna Maria\} and Essack, \{Sabiha Y.\} and Helmia Farida and Joveria Farooqi and Nicholas Feasey and Cecilia Ferreyra and Helen Fifer and Heather Finlayson and Mike Frick and Gales, \{Ana Cristina\} and Luisa Galli and Sumanth Gandra and Gerber, \{Jeffrey S.\} and Christian Giske and Bruce Gordon and Nelesh Govender and Nathalie Guessennd and Ibrehima Guindo and Elmira Gurbanova and Amanda Gwee and Ferry Hagen and Stephan Harbarth and John Haze and Jutta Heim and Rene Hendriksen and Heyderman, \{Robert Simon\} and Holt, \{Kathryn Elizabeth\} and Martin H{\"o}nigl and Hook, \{Edward W.\} and William Hope and Heidi Hopkins and Gwenda Hughes and Ghada Ismail and Issack, \{Mohammad Iqbal\} and Jan Jacobs and Du{\v s}an Jasovsk{\'y} and Fyeza Jehan and Pearson, \{Antonieta Jimenez\} and Makoto Jones and Joshi, \{Mohan P.\} and Arti Kapil and Samuel Kariuki and Abhilasha Karkey and Kearns, \{Gregory L.\} and Keddy, \{Karen Helena\} and Nina Khanna and Akiko Kitamura and Kolho, \{Kaija Leena\} and Kontoyiannis, \{Dimitrios P.\} and Anita Kotwani and Kozlov, \{Roman S.\} and Katharina Kranzer and Ranmini Kularatne and Lahra, \{Monica M.\} and Langford, \{Bradley J.\} and Rafael Laniado-Laborin and Joakim Larsson and Cornelia Lass-Fl{\"o}rl and \{Le Doare\}, Kirsty and Hyukmin Lee and Fernanda Lessa and Levin, \{Anna S.\} and Direk Limmathurotsakul and Nilton Lincopan and \{Lo Vecchio\}, Andrea and Rakesh Lodha and Mark Loeb and Yves Longtin and Lye, \{David Chien\} and Mahmud, \{Asif Mujtaba\} and C{\'e}lia Manaia and Lenore Manderson and Ivana Marekovi{\'c} and Kalisvar Marimuthu and Irene Martin and Tapfumanei Mashe and Zeng Mei and Meis, \{Jacques F.\} and \{Lyra Tavares De Melo\}, \{Fl{\'a}vio Augusto\} and Marc Mendelson and Miranda, \{Angelica Espinosa\} and David Moore and Chantal Morel and Nyambura Moremi and Moro, \{Maria Luisa\} and Francis Moussy and Stephen Mshana and Arno Mueller and Ndow, \{Francis J.\} and Mark Nicol and Andrew Nunn and Stephen Obaro and Obiero, \{Christina W.\} and Okeke, \{Iruka N.\} and Uduak Okomo and Okwor, \{Tochi J.\} and Rita Oladele and Sylvia Omulo and Pascale Ondoa and \{Ortellado de Canese\}, \{Juana Medarda\}",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = nov,

doi = "10.1016/S2666-5247(24)00134-4",

language = "English",

volume = "5",

journal = "The Lancet Microbe",

issn = "2666-5247",

number = "11",

}

TY - JOUR

T1 - WHO global research priorities for antimicrobial resistance in human health

AU - WHO Research Agenda for AMR in Human Health Collaborators

AU - Bertagnolio, Silvia

AU - Dobreva, Zlatina

AU - Centner, Chad M.

AU - Olaru, Ioana Diana

AU - Donà, Daniele

AU - Burzo, Stefano

AU - Huttner, Benedikt D.

AU - Chaillon, Antoine

AU - Gebreselassie, Nebiat

AU - Wi, Teodora

AU - Hasso-Agopsowicz, Mateusz

AU - Allegranzi, Benedetta

AU - Sati, Hatim

AU - Ivanovska, Verica

AU - Kothari, Kavita U.

AU - Balkhy, Hanan H.

AU - Cassini, Alessandro

AU - Hamers, Raph L.

AU - Weezenbeek, Kitty Van

AU - Aanensen, David

AU - Alanio, Alexandre

AU - Alastruey-Izquierdo, Ana

AU - Alemayehu, Tinsae

AU - Al-Hasan, Majdi

AU - Allegaert, Karel

AU - Al-Maani, Amal Saif

AU - Al-Salman, Jameela

AU - Alshukairi, Abeer Nizar

AU - Amir, Afreenish

AU - Applegate, Tanya

AU - Araj, George F.

AU - Villalobos, Marlen Arce

AU - Årdal, Christine

AU - Ashiru-Oredope, Diane

AU - Ashley, Elizabeth A.

AU - Babin, François Xavier

AU - Bachmann, Laura H.

AU - Bachmann, Till

AU - Baker, Kate Susan

AU - Balasegaram, Manica

AU - Bamford, Colleen

AU - Baquero, Fernando

AU - Barcelona, Laura Isabel

AU - Bassat, Quique

AU - Bassetti, Matteo

AU - Basu, Sulagna

AU - Beardsley, Justin

AU - Vásquez, Grey Benoit

AU - Berkley, James A.

AU - Bhatnagar, Anuj K.

AU - Bielicki, Julia

AU - Bines, Julie

AU - Bongomin, Felix

AU - Bonomo, Robert A.

AU - Bradley, John S.

AU - Bradshaw, Catriona

AU - Brett, Ana

AU - Brink, Adrian

AU - Brown, Colin

AU - Brown, Jeremy

AU - Buising, Kirsty

AU - Carson, Carolee

AU - Carvalho, Anna Cristina

AU - Castagnola, Elio

AU - Cavaleri, Marco

AU - Cecchini, Michele

AU - Chabala, Chishala

AU - Chaisson, Richard E.

AU - Chakrabarti, Arunaloke

AU - Chandler, Clare

AU - Chandy, Sujith John

AU - Charani, Esmita

AU - Chen, Lisa

AU - Chiara, Francesca

AU - Chowdhary, Anuradha

AU - Chua, Arlene

AU - Chuki, Pem

AU - Chun, Doo Ryeon

AU - Churchyard, Gavin

AU - Cirillo, Daniela

AU - Clack, Lauren

AU - Coffin, Susan E.

AU - Cohn, Jennifer

AU - Cole, Michelle

AU - Conly, John

AU - Cooper, Ben

AU - Corso, Alejandra

AU - Cosgrove, Sara E.

AU - Cox, Helen

AU - Daley, Charles L.

AU - Darboe, Saffiatou

AU - Darton, Tom

AU - Davies, Gerry

AU - de Egea, Viviana

AU - Dedeić-Ljubović, Amela

AU - Deeves, Miranda

AU - Denkinger, Claudia

AU - Dillon, Jo Anne R.

AU - Dramowski, Angela

AU - Eley, Brian

AU - Roberta Esposito, Susanna Maria

AU - Essack, Sabiha Y.

AU - Farida, Helmia

AU - Farooqi, Joveria

AU - Feasey, Nicholas

AU - Ferreyra, Cecilia

AU - Fifer, Helen

AU - Finlayson, Heather

AU - Frick, Mike

AU - Gales, Ana Cristina

AU - Galli, Luisa

AU - Gandra, Sumanth

AU - Gerber, Jeffrey S.

AU - Giske, Christian

AU - Gordon, Bruce

AU - Govender, Nelesh

AU - Guessennd, Nathalie

AU - Guindo, Ibrehima

AU - Gurbanova, Elmira

AU - Gwee, Amanda

AU - Hagen, Ferry

AU - Harbarth, Stephan

AU - Haze, John

AU - Heim, Jutta

AU - Hendriksen, Rene

AU - Heyderman, Robert Simon

AU - Holt, Kathryn Elizabeth

AU - Hönigl, Martin

AU - Hook, Edward W.

AU - Hope, William

AU - Hopkins, Heidi

AU - Hughes, Gwenda

AU - Ismail, Ghada

AU - Issack, Mohammad Iqbal

AU - Jacobs, Jan

AU - Jasovský, Dušan

AU - Jehan, Fyeza

AU - Pearson, Antonieta Jimenez

AU - Jones, Makoto

AU - Joshi, Mohan P.

AU - Kapil, Arti

AU - Kariuki, Samuel

AU - Karkey, Abhilasha

AU - Kearns, Gregory L.

AU - Keddy, Karen Helena

AU - Khanna, Nina

AU - Kitamura, Akiko

AU - Kolho, Kaija Leena

AU - Kontoyiannis, Dimitrios P.

AU - Kotwani, Anita

AU - Kozlov, Roman S.

AU - Kranzer, Katharina

AU - Kularatne, Ranmini

AU - Lahra, Monica M.

AU - Langford, Bradley J.

AU - Laniado-Laborin, Rafael

AU - Larsson, Joakim

AU - Lass-Flörl, Cornelia

AU - Le Doare, Kirsty

AU - Lee, Hyukmin

AU - Lessa, Fernanda

AU - Levin, Anna S.

AU - Limmathurotsakul, Direk

AU - Lincopan, Nilton

AU - Lo Vecchio, Andrea

AU - Lodha, Rakesh

AU - Loeb, Mark

AU - Longtin, Yves

AU - Lye, David Chien

AU - Mahmud, Asif Mujtaba

AU - Manaia, Célia

AU - Manderson, Lenore

AU - Mareković, Ivana

AU - Marimuthu, Kalisvar

AU - Martin, Irene

AU - Mashe, Tapfumanei

AU - Mei, Zeng

AU - Meis, Jacques F.

AU - Lyra Tavares De Melo, Flávio Augusto

AU - Mendelson, Marc

AU - Miranda, Angelica Espinosa

AU - Moore, David

AU - Morel, Chantal

AU - Moremi, Nyambura

AU - Moro, Maria Luisa

AU - Moussy, Francis

AU - Mshana, Stephen

AU - Mueller, Arno

AU - Ndow, Francis J.

AU - Nicol, Mark

AU - Nunn, Andrew

AU - Obaro, Stephen

AU - Obiero, Christina W.

AU - Okeke, Iruka N.

AU - Okomo, Uduak

AU - Okwor, Tochi J.

AU - Oladele, Rita

AU - Omulo, Sylvia

AU - Ondoa, Pascale

AU - Ortellado de Canese, Juana Medarda

PY - 2024/11

Y1 - 2024/11

N2 - The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

AB - The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

UR - https://www.scopus.com/pages/publications/85201120507

U2 - 10.1016/S2666-5247(24)00134-4

DO - 10.1016/S2666-5247(24)00134-4

M3 - Review article

C2 - 39146948

AN - SCOPUS:85201120507

SN - 2666-5247

VL - 5

JO - The Lancet Microbe

JF - The Lancet Microbe

IS - 11

M1 - 100902

ER -

WHO global research priorities for antimicrobial resistance in human health

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