TY - JOUR
T1 - WHF Roadmap on Single Pill Combination Therapies
AU - Ferro, Enrico G.
AU - Satheesh, Gautam
AU - Castellano, José
AU - Damasceno, Albertino
AU - Erojikwe, Okeoma
AU - Huffman, Mark
AU - Irazola, Vilma
AU - Joseph, Philip
AU - Lanas, Fernando
AU - Ogola, Elijah
AU - Ordunez, Pedro
AU - Perel, Pablo
AU - Pineiro, Daniel
AU - Uchmanowicz, Izabela
AU - Vardeny, Orly
AU - Webster, Ruth
AU - Gamra, Habib
AU - Gaziano, Thomas
AU - Murphy, Adrianna
N1 - Publisher Copyright:
COPYRIGHT: © 2025 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
PY - 2025
Y1 - 2025
N2 - Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially in low- and middle-income countries. It serves as a tool for policymakers, clinicians, and advocates to drive progress in aligning cardiovascular prevention efforts with evidence-based, people-centred care.
AB - Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially in low- and middle-income countries. It serves as a tool for policymakers, clinicians, and advocates to drive progress in aligning cardiovascular prevention efforts with evidence-based, people-centred care.
KW - Cardiovascular disease
KW - polypill
KW - prevention
KW - single pill combinations
UR - https://www.scopus.com/pages/publications/105015031247
U2 - 10.5334/gh.1457
DO - 10.5334/gh.1457
M3 - Article
C2 - 40894085
AN - SCOPUS:105015031247
SN - 2211-8160
VL - 20
JO - Global Heart
JF - Global Heart
IS - 1
M1 - 73
ER -