Where orthobiologics started: what are mesenchymal stem cells?

Garrett R. Jackson; Derrick M. Knapik; Felicitas Allende; Daniel J. Kaplan; Jorge Chahla; Kenneth R. Zaslav

doi:10.1016/B978-0-12-822902-6.00013-1

Where orthobiologics started: what are mesenchymal stem cells?

Garrett R. Jackson
, Derrick M. Knapik
, Felicitas Allende
, Daniel J. Kaplan
, Jorge Chahla
, Kenneth R. Zaslav

Division of Sport Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Orthobiologics comprise biological products derived from human or animal tissues used to promote healing and regeneration in the treatment of various orthopedic conditions. The discovery of orthobiologics has opened a new avenue in the treatment of orthopedic injuries, particularly with the increased interest and utilization of mesenchymal stem cells (MSCs). MSCs are nonhematopoietic progenitor cells with the potential for self-replication, self-division, self-renewal, cellular regeneration, and multipotency. This chapter aims to discuss the historical use of orthobiologics and the orthopedic conditions that orthobiologics are used to treat in current practice.

Original language	English
Title of host publication	OrthoBiologics
Publisher	Elsevier
Pages	31-37
Number of pages	7
ISBN (Electronic)	9780128229026
ISBN (Print)	9780128229033
DOIs	https://doi.org/10.1016/B978-0-12-822902-6.00013-1
State	Published - Jan 1 2024

Keywords

bone graft
bone marrow aspirate concentrate
Mesenchymal stem cells
orthobiologics
platelet-rich plasma

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10.1016/B978-0-12-822902-6.00013-1

Cite this

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title = "Where orthobiologics started: what are mesenchymal stem cells?",

abstract = "Orthobiologics comprise biological products derived from human or animal tissues used to promote healing and regeneration in the treatment of various orthopedic conditions. The discovery of orthobiologics has opened a new avenue in the treatment of orthopedic injuries, particularly with the increased interest and utilization of mesenchymal stem cells (MSCs). MSCs are nonhematopoietic progenitor cells with the potential for self-replication, self-division, self-renewal, cellular regeneration, and multipotency. This chapter aims to discuss the historical use of orthobiologics and the orthopedic conditions that orthobiologics are used to treat in current practice.",

keywords = "bone graft, bone marrow aspirate concentrate, Mesenchymal stem cells, orthobiologics, platelet-rich plasma",

author = "Jackson, \{Garrett R.\} and Knapik, \{Derrick M.\} and Felicitas Allende and Kaplan, \{Daniel J.\} and Jorge Chahla and Zaslav, \{Kenneth R.\}",

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doi = "10.1016/B978-0-12-822902-6.00013-1",

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T1 - Where orthobiologics started

T2 - what are mesenchymal stem cells?

AU - Jackson, Garrett R.

AU - Knapik, Derrick M.

AU - Allende, Felicitas

AU - Kaplan, Daniel J.

AU - Chahla, Jorge

AU - Zaslav, Kenneth R.

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Orthobiologics comprise biological products derived from human or animal tissues used to promote healing and regeneration in the treatment of various orthopedic conditions. The discovery of orthobiologics has opened a new avenue in the treatment of orthopedic injuries, particularly with the increased interest and utilization of mesenchymal stem cells (MSCs). MSCs are nonhematopoietic progenitor cells with the potential for self-replication, self-division, self-renewal, cellular regeneration, and multipotency. This chapter aims to discuss the historical use of orthobiologics and the orthopedic conditions that orthobiologics are used to treat in current practice.

AB - Orthobiologics comprise biological products derived from human or animal tissues used to promote healing and regeneration in the treatment of various orthopedic conditions. The discovery of orthobiologics has opened a new avenue in the treatment of orthopedic injuries, particularly with the increased interest and utilization of mesenchymal stem cells (MSCs). MSCs are nonhematopoietic progenitor cells with the potential for self-replication, self-division, self-renewal, cellular regeneration, and multipotency. This chapter aims to discuss the historical use of orthobiologics and the orthopedic conditions that orthobiologics are used to treat in current practice.

KW - bone graft

KW - bone marrow aspirate concentrate

KW - Mesenchymal stem cells

KW - orthobiologics

KW - platelet-rich plasma

UR - https://www.scopus.com/pages/publications/85205193780

U2 - 10.1016/B978-0-12-822902-6.00013-1

DO - 10.1016/B978-0-12-822902-6.00013-1

M3 - Chapter

AN - SCOPUS:85205193780

SN - 9780128229033

SP - 31

EP - 37

BT - OrthoBiologics

PB - Elsevier

ER -

Where orthobiologics started: what are mesenchymal stem cells?

Abstract

Keywords

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