When your cap matters: Structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Cytosolic recognition of viral RNA is important for host innate immune responses. Differential recognition of self vs non-self RNA is a considerable challenge as the inability to differentiate may trigger aberrant immune responses. Recent work identified the composition of the RNA 5', including the 5' cap and its methylation state, as an important determinant of recognition by the host. Recent studies have advanced our understanding of the modified 5' RNA recognition and viral antagonism of RNA receptors. Here, we will discuss RIG-I and IFIT proteins as examples of host proteins that detect dsRNA and ssRNA, respectively.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume36
DOIs
StatePublished - Feb 1 2016

Fingerprint

Dive into the research topics of 'When your cap matters: Structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins'. Together they form a unique fingerprint.

Cite this