When T cells run out of breath: The HIF-1α story

Katherine Nutsch; Chyi Hsieh

doi:10.1016/j.cell.2011.08.018

When T cells run out of breath: The HIF-1α story

Katherine Nutsch, Chyi Hsieh

Research output: Contribution to journal › Short survey › peer-review

12 Scopus citations

Abstract

In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1α in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.

Original language	English
Pages (from-to)	673-674
Number of pages	2
Journal	Cell
Volume	146
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2011.08.018
State	Published - Sep 2 2011

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title = "When T cells run out of breath: The HIF-1α story",

abstract = "In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1α in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.",

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T2 - The HIF-1α story

AU - Nutsch, Katherine

AU - Hsieh, Chyi

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N2 - In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1α in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.

AB - In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1α in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.

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U2 - 10.1016/j.cell.2011.08.018

DO - 10.1016/j.cell.2011.08.018

M3 - Short survey

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AN - SCOPUS:80052276718

SN - 0092-8674

VL - 146

SP - 673

EP - 674

JO - Cell

JF - Cell

IS - 5

ER -

When T cells run out of breath: The HIF-1α story

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