TY - JOUR
T1 - When STING Meets Viruses
T2 - Sensing, Trafficking and Response
AU - Li, Zhaohe
AU - Cai, Siqi
AU - Sun, Yutong
AU - Li, Li
AU - Ding, Siyuan
AU - Wang, Xin
N1 - Publisher Copyright:
© Copyright © 2020 Li, Cai, Sun, Li, Ding and Wang.
PY - 2020/9/29
Y1 - 2020/9/29
N2 - To effectively defend against microbial pathogens, the host cells mount antiviral innate immune responses by producing interferons (IFNs), and hundreds of IFN-stimulated genes (ISGs). Upon recognition of cytoplasmic viral or bacterial DNAs and abnormal endogenous DNAs, the DNA sensor cGAS synthesizes 2’,3’-cGAMP that induces STING (stimulator of interferon genes) undergoing conformational changes, cellular trafficking, and the activation of downstream factors. Therefore, STING plays a pivotal role in preventing microbial pathogen infection by sensing DNAs during pathogen invasion. This review is dedicated to the recent advances in the dynamic regulations of STING activation, intracellular trafficking, and post-translational modifications (PTMs) by the host and microbial proteins.
AB - To effectively defend against microbial pathogens, the host cells mount antiviral innate immune responses by producing interferons (IFNs), and hundreds of IFN-stimulated genes (ISGs). Upon recognition of cytoplasmic viral or bacterial DNAs and abnormal endogenous DNAs, the DNA sensor cGAS synthesizes 2’,3’-cGAMP that induces STING (stimulator of interferon genes) undergoing conformational changes, cellular trafficking, and the activation of downstream factors. Therefore, STING plays a pivotal role in preventing microbial pathogen infection by sensing DNAs during pathogen invasion. This review is dedicated to the recent advances in the dynamic regulations of STING activation, intracellular trafficking, and post-translational modifications (PTMs) by the host and microbial proteins.
KW - DNA viruses
KW - STING
KW - cellular trafficking
KW - immune responses
KW - post translational modifications
UR - http://www.scopus.com/inward/record.url?scp=85092734927&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2020.02064
DO - 10.3389/fimmu.2020.02064
M3 - Review article
C2 - 33133062
AN - SCOPUS:85092734927
SN - 1664-3224
VL - 11
JO - Frontiers in immunology
JF - Frontiers in immunology
M1 - 2064
ER -