When inflammation is not just inflammation—A review of systemic diseases of the nose and sinuses part 1: IgG4-related disease and sarcoidosis

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Abstract

Background: Chronic rhinosinusitis is a very common condition. IgG4-related disease (IgG4-RD) and sarcoidosis are systemic diseases which can contribute to the development of chronic rhinosinusitis in select patients. Objective: Characterize the presenting features, diagnostic criteria, workup, and management of sinonasal IgG4-RD and sarcoidosis as they are encountered in otolaryngology clinics. Methods: Full length manuscripts published 2000 or later were reviewed. A separate search was conducted for each disease. Pertinent clinical features related to sinonasal manifestations of IgG4-RD and sarcoidosis were collected and reported in this review. Results: 404 references were discovered during literature review process. In total, 42 references for IgG4-RD and 34 references for sarcoidosis were included in this review. Conclusion: IgG4-RD and sarcoidosis are autoimmune inflammatory conditions that can affect many systems of the body. For both disease entities, sinonasal disease is a less common presentation which can lead to delayed diagnosis. Sinonasal IgG4-RD commonly presents in the setting of multisystem disease. All with other clinical features, biopsy plays a key role in the diagnosis for both diseases. Treatment for IgG4-RD consists primarily of steroids and rituximab which can lead to excellent and durable remission. A variety of immunosuppressive agents are used in the management of sarcoidosis. Surgery for IgG4-RD is primarily utilized for tissue biopsy, although resection or debulking may be considered. For sarcoidosis, surgery can be used for tissue biopsy and functional sinus surgery can offer symptomatic relief in many patients.

Original languageEnglish
Article number104213
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume45
Issue number3
DOIs
StatePublished - May 1 2024

Keywords

  • Autoimmune
  • Chronic rhinosinusitis
  • Histopathology
  • IgG4-related disease
  • Immunosuppression
  • Inflammation
  • Sarcoidosis
  • Sinusitis
  • Steroid
  • Systemic

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