Reduced folate levels can cause developmental defects and megaloblastic anemia. Padmanabhan et al. (2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descendants for up to four generations.

Original languageEnglish
Pages (from-to)457-459
Number of pages3
JournalCell metabolism
Issue number4
StatePublished - Oct 1 2013


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