TY - CHAP
T1 - What doesn’t belong and why
T2 - A saga of latency associated proteins elaborated by varicella zoster virus
AU - Walters, Matthew S.
AU - Kyratsous, Christos A.
AU - Stallings, Christina L.
AU - Lungu, Octavian
AU - Walters, Matthew S.
N1 - Publisher Copyright:
© 2012 by World Scientific Publishing Co. Pte. Ltd. All rights reserved.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - The proclivity with which human alpha herpesviruses establish latent infections in neural ganglia is manifest by the presence of their viral genomes as multiple nonreplicating nuclear episomes.1 This penchant for residing in neurons presents a puzzling problem for these viruses. In particular they must negotiate a life-cycle in non-dividing cells that fail to express host proteins that are required for their replication or may even express proteins that result in a block to replication. While there is no obvious solution to this problem, replicate they do as evidenced by their ability to reactivate. A question that occurs is; what are these viruses doing while they lay in wait, to replicate, descend the axon and pronounce their appearance as overt local lesions? This is a problem that the laboratory has tried to address, with varied success, during the past 15 years.
AB - The proclivity with which human alpha herpesviruses establish latent infections in neural ganglia is manifest by the presence of their viral genomes as multiple nonreplicating nuclear episomes.1 This penchant for residing in neurons presents a puzzling problem for these viruses. In particular they must negotiate a life-cycle in non-dividing cells that fail to express host proteins that are required for their replication or may even express proteins that result in a block to replication. While there is no obvious solution to this problem, replicate they do as evidenced by their ability to reactivate. A question that occurs is; what are these viruses doing while they lay in wait, to replicate, descend the axon and pronounce their appearance as overt local lesions? This is a problem that the laboratory has tried to address, with varied success, during the past 15 years.
UR - http://www.scopus.com/inward/record.url?scp=84973161261&partnerID=8YFLogxK
U2 - 10.1142/9789814338998_0002
DO - 10.1142/9789814338998_0002
M3 - Chapter
AN - SCOPUS:84973161261
SN - 9789814338981
SP - 23
EP - 57
BT - From the Hallowed Halls of Herpesvirology
PB - World Scientific Publishing Co.
ER -