West Nile virus infection and immunity

Mehul S. Suthar; Michael S. Diamond; Michael Gale

doi:10.1038/nrmicro2950

West Nile virus infection and immunity

Mehul S. Suthar, Michael S. Diamond, Michael Gale

Research output: Contribution to journal › Review article › peer-review

323 Scopus citations

Abstract

West Nile virus (WNV) is an emerging neurotropic flavivirus that is transmitted to humans through the bite of an infected mosquito. WNV has disseminated broadly in the Western hemisphere and now poses a significant public health risk. The continuing spread of WNV, combined with the lack of specific therapeutics or vaccines to combat or prevent infection, imparts a pressing need to identify the viral and host processes that control the outcome of and immunity to WNV infection. Here, we provide an overview of recent research that has revealed the virus-host interface controlling WNV infection and immunity.

Original language	English
Pages (from-to)	115-128
Number of pages	14
Journal	Nature Reviews Microbiology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1038/nrmicro2950
State	Published - Feb 2013

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10.1038/nrmicro2950

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abstract = "West Nile virus (WNV) is an emerging neurotropic flavivirus that is transmitted to humans through the bite of an infected mosquito. WNV has disseminated broadly in the Western hemisphere and now poses a significant public health risk. The continuing spread of WNV, combined with the lack of specific therapeutics or vaccines to combat or prevent infection, imparts a pressing need to identify the viral and host processes that control the outcome of and immunity to WNV infection. Here, we provide an overview of recent research that has revealed the virus-host interface controlling WNV infection and immunity.",

author = "Suthar, {Mehul S.} and Diamond, {Michael S.} and Michael Gale",

note = "Funding Information: Work from the Gale laboratory has been supported by the US National Institutes of Health (NIH) and Burroughs Wellcome. The Diamond laboratory has been supported by the US NIH. The authors thank B. Doehle and H. Ramos for comments and manuscript revisions, and apologize to the many authors whose work could not be cited owing to space constraints.",

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AU - Gale, Michael

N1 - Funding Information: Work from the Gale laboratory has been supported by the US National Institutes of Health (NIH) and Burroughs Wellcome. The Diamond laboratory has been supported by the US NIH. The authors thank B. Doehle and H. Ramos for comments and manuscript revisions, and apologize to the many authors whose work could not be cited owing to space constraints.

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AB - West Nile virus (WNV) is an emerging neurotropic flavivirus that is transmitted to humans through the bite of an infected mosquito. WNV has disseminated broadly in the Western hemisphere and now poses a significant public health risk. The continuing spread of WNV, combined with the lack of specific therapeutics or vaccines to combat or prevent infection, imparts a pressing need to identify the viral and host processes that control the outcome of and immunity to WNV infection. Here, we provide an overview of recent research that has revealed the virus-host interface controlling WNV infection and immunity.

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West Nile virus infection and immunity

Abstract

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