West Nile virus infection and immunity

Mehul S. Suthar, Michael S. Diamond, Michael Gale

Research output: Contribution to journalReview articlepeer-review

233 Scopus citations

Abstract

West Nile virus (WNV) is an emerging neurotropic flavivirus that is transmitted to humans through the bite of an infected mosquito. WNV has disseminated broadly in the Western hemisphere and now poses a significant public health risk. The continuing spread of WNV, combined with the lack of specific therapeutics or vaccines to combat or prevent infection, imparts a pressing need to identify the viral and host processes that control the outcome of and immunity to WNV infection. Here, we provide an overview of recent research that has revealed the virus-host interface controlling WNV infection and immunity.

Original languageEnglish
Pages (from-to)115-128
Number of pages14
JournalNature Reviews Microbiology
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2013

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