@article{b5827dc72d774717937f4423c16025ec,
title = "Weight Control Program and Gestational Weight Gain in Disadvantaged Women with Overweight or Obesity: A Randomized Clinical Trial",
abstract = "Objective: This study aimed to evaluate the efficacy of a home-based lifestyle intervention delivered through Parents as Teachers (PAT) to reduce excessive gestational weight gain (GWG). Methods: This was a single-blinded randomized controlled trial conducted as part of the LIFE-Moms consortium at a single university-based tertiary care institution from October 2012 to March 2016. There were 267 socioeconomically disadvantaged (SED) African American women with overweight or obesity (BMI 25.0-45.0 kg/m2 before pregnancy. Participants were randomized to therapy with standard PAT alone (n = 134) or PAT plus a lifestyle intervention program embedded within the standard PAT program (PAT+) (n = 133). Both interventions were delivered in 10 biweekly home visits during pregnancy. The primary outcome was the percentage of women whose GWG exceeded the Institute of Medicine guidelines, and secondary outcomes included both weekly and total GWG. Results: Compared with the standard PAT group in the intent-to-treat analysis, the PAT + group gained less weekly (0.4 kg vs. 0.5 kg/wk; P = 0.04) and total (8.0 kg vs. 9.6 kg; P = 0.02) weight during gestation. Fewer participants in the PAT + group had excessive total GWG (36.1% vs. 45.9%), but the difference between groups was not statistically significant (P = 0.11). Conclusions: PAT + reduced the weekly and total GWG in SED African American women with overweight or obesity at the start of pregnancy.",
author = "Cahill, {Alison G.} and Debra Haire-Joshu and Cade, {W. Todd} and Stein, {Richard I.} and Woolfolk, {Candice L.} and Kelle Moley and Amit Mathur and Kenneth Schechtman and Samuel Klein",
note = "Funding Information: We thank the LIFE-Moms consortium members for their contributions to the development and oversight of the common measures and procedures shared across the trials. Funding Information: See Commentary, pg. 459. Funding agencies: This work was supported by the National Institutes of Health grants DK094416, DK56341 (Nutrition Obesity Research Center), DK092950 (Center for Diabetes Translation Research), DK20579 (Diabetes Research Center), and RR024992 (Clinical and Translational Science Award). The Lifestyle Interventions for Expectant Moms (LIFE-Moms) consortium is supported by the National Institutes of Health (NIH) through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, U01 DK094418, U01 DK094463, U01 DK094416, 5U01 DK094466 [RCU]), the National Heart, Lung, and Blood Institute (U01 HL114344, U01 HL114377), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (U01 HD072834), the National Center for Complementary and Integrative Health, the NIH Office of Research in Women{\textquoteright}s Health, the Office of Behavioral and Social Science Research, the Indian Health Service, and the Intramural Research Program of the NIDDK. Disclosure: The authors declared no conflicts of interest. Author contributions: Study concept and design: AGC, SK, DHJ, WTC, RIS, AM, KM. Data collection: AGC, DHJ, WTC, RIS, KM, AM, SK. Analysis and interpretation of data: AGC, KS, SK, CLW. Drafting of manuscript: AGC, DHJ, WTC, RIS, CLW, KM, AM, SK. Critical revision of the manuscript: AGC, DHJ, WTC, RIS, CLW, KM, AM, SK. Obtain funding: AGC, SK, DHJ. Clinical trial registration: ClinicalTrials.gov identifier NCT01768793. Additional Supporting Information may be found in the online version of this article. Received: 3 October 2017; Accepted: 17 October 2017; Published online 21 February 2018. doi:10.1002/oby.22070 Publisher Copyright: {\textcopyright} 2018 The Obesity Society",
year = "2018",
month = mar,
doi = "10.1002/oby.22070",
language = "English",
volume = "26",
pages = "485--491",
journal = "Obesity",
issn = "1930-7381",
number = "3",
}