TY - JOUR
T1 - Weight change trends and overall survival in United States veterans with follicular lymphoma treated with chemotherapy
AU - Xiao, Daphne Y.
AU - Luo, Suhong
AU - O’Brian, Katiuscia
AU - Liu, Weijian
AU - Carson, Kenneth R.
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/4/3
Y1 - 2017/4/3
N2 - Understanding weight change patterns in follicular lymphoma (FL) may be important for the assessment of prognosis as well as the long-term care of survivors. A retrospective cohort of United States veterans with a new diagnosis of FL between October 1, 1998 and September 30, 2010 was assembled. Weight changes were evaluated before, during, and after treatment in 896 FL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisone, with or without rituximab (CHOP ± R); cyclophosphamide, vincristine, and prednisone, with or without rituximab (CVP ± R); or rituximab monotherapy. Weight decreased an average of 1.4 kg during therapy, and >5% weight loss during this time period was associated with worse overall survival. Weight increased to an average of 1.4 kg above baseline by 24 months after treatment initiation, with 15% gaining greater than 10% of their baseline weight. Weight management strategies may be an important part of long-term survivorship planning.
AB - Understanding weight change patterns in follicular lymphoma (FL) may be important for the assessment of prognosis as well as the long-term care of survivors. A retrospective cohort of United States veterans with a new diagnosis of FL between October 1, 1998 and September 30, 2010 was assembled. Weight changes were evaluated before, during, and after treatment in 896 FL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisone, with or without rituximab (CHOP ± R); cyclophosphamide, vincristine, and prednisone, with or without rituximab (CVP ± R); or rituximab monotherapy. Weight decreased an average of 1.4 kg during therapy, and >5% weight loss during this time period was associated with worse overall survival. Weight increased to an average of 1.4 kg above baseline by 24 months after treatment initiation, with 15% gaining greater than 10% of their baseline weight. Weight management strategies may be an important part of long-term survivorship planning.
KW - Body weight changes
KW - lymphoma
KW - veterans
UR - http://www.scopus.com/inward/record.url?scp=84988692331&partnerID=8YFLogxK
U2 - 10.1080/10428194.2016.1217526
DO - 10.1080/10428194.2016.1217526
M3 - Article
C2 - 27669828
AN - SCOPUS:84988692331
SN - 1042-8194
VL - 58
SP - 851
EP - 858
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 4
ER -