TY - JOUR
T1 - Weight as a risk factor for clinical diabetes in women
AU - Colditz, Graham A.
AU - Willett, Walter C.
AU - Stampfer, Meir J.
AU - Manson, Joann E.
AU - Hennekens, Charles H.
AU - Arky, Ronald A.
AU - Speizer, Frank E.
N1 - Funding Information:
MA. Reprint requests to Dr. G. A. Colditz, Channing Laboratory, 180 Longwood Avenue, Boston, MA 02115-5899. Supported by research grants DK 36798, CA 40935, and CA 40356 from the National Institutes of Health. The authors thank the registered nurses who participated in the study. David Dysert, Maureen Ireland, Barbara Egan, Susan Newman, Debbie O'Sullivan, Martin VanDenburg, Marion McPhee, Karen Cor-sano, and Mark Shneyder provided unfailing help.
PY - 1990/9
Y1 - 1990/9
N2 - To determine the relation of body mass index (weight/height2) with the risk of clinical non-insulin-dependent diabetes, the authors analyzed data from a cohort of 113,861 US women aged 30-55 years in 1976. During 8 years of follow-up (826,010 person-years), 873 definite cases were identified among women initially free from diagnosed diabetes. Among women of average body mass index, 23-23.9 kg/m2 the relative risk was 3.6 times that of women having a body mass index less than 22 kg/m2 The risk continued to increase above this level of body mass index. The authors observed a much weaker positive association with weight at age 18, and this association was eliminated after adjustment for current body mass index. Thus, weight gain after age 18 was a major determinant of risk. For an increase of 20-35 kg, the relative risk was 11.3, and for an increase of more than 35 kg, the relative risk was 17.3. Adjusting for family history did not appreciably alter the strong relation observed among women at average levels of body mass index. These data indicate that, at even average weight, women are at increased risk of clinical non-insulin-dependent diabetes and that the relation between body mass index and risk of diabetes is continuous.
AB - To determine the relation of body mass index (weight/height2) with the risk of clinical non-insulin-dependent diabetes, the authors analyzed data from a cohort of 113,861 US women aged 30-55 years in 1976. During 8 years of follow-up (826,010 person-years), 873 definite cases were identified among women initially free from diagnosed diabetes. Among women of average body mass index, 23-23.9 kg/m2 the relative risk was 3.6 times that of women having a body mass index less than 22 kg/m2 The risk continued to increase above this level of body mass index. The authors observed a much weaker positive association with weight at age 18, and this association was eliminated after adjustment for current body mass index. Thus, weight gain after age 18 was a major determinant of risk. For an increase of 20-35 kg, the relative risk was 11.3, and for an increase of more than 35 kg, the relative risk was 17.3. Adjusting for family history did not appreciably alter the strong relation observed among women at average levels of body mass index. These data indicate that, at even average weight, women are at increased risk of clinical non-insulin-dependent diabetes and that the relation between body mass index and risk of diabetes is continuous.
KW - Diabetes mellitus, non-insulin-dependent
KW - Incidence
KW - Obesity
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=0025148179&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.aje.a115686
DO - 10.1093/oxfordjournals.aje.a115686
M3 - Article
C2 - 2389754
AN - SCOPUS:0025148179
SN - 0002-9262
VL - 132
SP - 501
EP - 513
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 3
ER -