TY - JOUR
T1 - Walking track analysis
T2 - A long-term assessment of peripheral nerve recovery
AU - Hare, G. M.
AU - Evans, P. J.
AU - Mackinnon, S. E.
AU - Best, T. J.
AU - Bain, J. R.
AU - Szalai, J. P.
AU - Hunter, D. A.
PY - 1992/2
Y1 - 1992/2
N2 - Functional recovery following sciatic, tibial, and peroneal nerve injury was assessed over a 1-year period using walking track analysis in the rat. Internal neurolysis did not affect nerve function. Crush injury induced a temporary, but complete, loss of function that recovered to control levels by 4 weeks. Nerve transection resulted in complete loss of function without any evidence of recovery. After nerve repair, functional recovery occurred, reaching near-optimal recovery by 12 weeks. The degree of functional recovery varied with the specific nerve involved. The sciatic nerve recovered 41 percent of function, whereas the tibial nerve recovered 54 percent of function. The peroneal nerve exhibited the highest degree of recovery, achieving functional levels similar to control values. Assessment of neural regeneration using walking track analysis appears to be a valuable addition to the traditional methods of histology and electrophysiology.
AB - Functional recovery following sciatic, tibial, and peroneal nerve injury was assessed over a 1-year period using walking track analysis in the rat. Internal neurolysis did not affect nerve function. Crush injury induced a temporary, but complete, loss of function that recovered to control levels by 4 weeks. Nerve transection resulted in complete loss of function without any evidence of recovery. After nerve repair, functional recovery occurred, reaching near-optimal recovery by 12 weeks. The degree of functional recovery varied with the specific nerve involved. The sciatic nerve recovered 41 percent of function, whereas the tibial nerve recovered 54 percent of function. The peroneal nerve exhibited the highest degree of recovery, achieving functional levels similar to control values. Assessment of neural regeneration using walking track analysis appears to be a valuable addition to the traditional methods of histology and electrophysiology.
UR - http://www.scopus.com/inward/record.url?scp=0026529122&partnerID=8YFLogxK
U2 - 10.1097/00006534-199202000-00009
DO - 10.1097/00006534-199202000-00009
M3 - Article
C2 - 1732892
AN - SCOPUS:0026529122
SN - 0032-1052
VL - 89
SP - 251
EP - 258
JO - Plastic and reconstructive surgery
JF - Plastic and reconstructive surgery
IS - 2
ER -