Waking experience affects sleep need in Drosophila

Indrani Ganguly-Fitzgerald, Jeff Donlea, Paul J. Shaw

Research output: Contribution to journalArticlepeer-review

222 Scopus citations


Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecular connection between sleep, plasticity, and memory formation has been difficult to demonstrate. We establish Drosophila as a model to investigate this relation and demonstrate that the intensity and/or complexity of prior social experience stably modifies sleep need and architecture. Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3′,5′- monophosphate signaling pathways and a particular subset of 17 long-term memory genes.

Original languageEnglish
Pages (from-to)1775-1781
Number of pages7
Issue number5794
StatePublished - Sep 22 2006


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