Von Willebrand Factor and Platelet Aggregation: from Bench to Clinical Practice

Purpose of Review: This review describes von Willebrand factor (VWF)-mediated platelet function in inherited and acquired bleeding disorders, and current and novel approaches from bench to clinical practice used to perform research, diagnose, and treat bleeding disorders. Recent Findings: Patients can present with either qualitative or quantitative defects in VWF and/or platelets, which can be inherited or acquired. Understanding the structure–function relationships of VWF and platelets has led to clinically useful classification and treatment of coagulopathy. However, current bench and clinical assays can be time-consuming and have limitations that preclude assessment of important mechanistic drivers, including physiologically relevant flow conditions pertinent to VWF-mediated platelet function. Summary: The purpose of this review is to discuss current and traditional laboratory-based assessment of VWF-mediated platelet function and the translation to clinical practice with specific focus on patient bleeding risks and the tools available for their management.