von Willebrand Disease: Diagnostic Strategies and Treatment Options

Christopher J. Ng, Jorge Di Paola

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


von Willebrand disease (VWD) is one of the most common inherited bleeding disorders. Since its first description in 1926, the diagnosis and management of VWD has significantly improved due to increasing scientific knowledge of the genetics and biology of von Willebrand factor (VWF). This article reviews the molecular structure and function of VWF as well as the clinical symptoms, laboratory-based diagnostic workup, and classification schema for VWD. It highlights current treatment options and state-of-the art research in VWF and VWD.

Original languageEnglish
Pages (from-to)527-541
Number of pages15
JournalPediatric Clinics of North America
Issue number3
StatePublished - Jun 2018


  • Mucocutaneous bleeding
  • von Willebrand disease
  • von Willebrand factor


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