Volumetric diffuse optical tomography of brain activity

Joseph P. Culver, Andrew M. Siegel, Jonathan J. Stott, David A. Boas

Research output: Contribution to journalArticlepeer-review

152 Scopus citations


We present three-dimensional diffuse optical tomography of the hemodynamic response to somatosensory stimulation in a rat. These images show the feasibility of volumetrically imaging the functional response to brain activity with diffuse light. A combination of positional optode calibration and contrast-to-noise ratio weighting was found to improve imaging performance.

Original languageEnglish
Pages (from-to)2061-2063
Number of pages3
JournalOptics Letters
Issue number21
StatePublished - Nov 1 2003


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