Voltage-Dependent Calcium Channels (CaVs) and CatSper in Spermatogenic and Sperm Cells

Alberto Darszon; Juan J. Ferreira; Ignacio López-González; Gerardo Orta; Claudia L. Treviño; Celia M. Santi

doi:10.1007/978-3-031-08881-0_23

Voltage-Dependent Calcium Channels (CaVs) and CatSper in Spermatogenic and Sperm Cells

Alberto Darszon, Juan J. Ferreira, Ignacio López-González, Gerardo Orta, Claudia L. Treviño, Celia M. Santi

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

As in most cell types, intracellular Ca²⁺ regulates many fundamental physiological functions in sperm and its progenitors. Ca²⁺ permeable and voltage-dependent channels in their plasma membrane deeply influence the intracellular Ca²⁺ concentration. Notably, the role of traditional voltage-dependent Ca²⁺ channels (Ca_Vs) in spermatogenesis, sperm maturation, motility, and preparation for egg fusion is not well defined. Sperm possesses a unique and very complex Ca²⁺ channel regulated by intracellular pH, Ca²⁺, and voltage called CatSper that is key for fertilization and influences motility, and possibly the acrosome reaction (AR). This exocytotic singular event encompasses the fusion of the acrosome vesicle in the posterior region of the head to the plasma membrane preparing this cell to fuse and fertilize the egg. Though Ca_Vs and CatSper may participate in this reaction, it is still a pending question. In this chapter, we examine the characteristics of these Ca²⁺ channels and their involvement in sperm physiology.

Original language	English
Title of host publication	Voltage-Gated Calcium Channels
Publisher	Springer International Publishing
Pages	599-634
Number of pages	36
ISBN (Electronic)	9783031088810
ISBN (Print)	9783031088803
DOIs	https://doi.org/10.1007/978-3-031-08881-0_23
State	Published - Jan 1 2022

Keywords

Acrosome reaction
CatSper channels
CatSper regulation
Chemotaxis
Hormonal regulation
Hyperactivation
Mammalian sperm
Rheotaxis
Spermatogenesis
Voltage-dependent Ca channels

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10.1007/978-3-031-08881-0_23

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abstract = "As in most cell types, intracellular Ca2+ regulates many fundamental physiological functions in sperm and its progenitors. Ca2+ permeable and voltage-dependent channels in their plasma membrane deeply influence the intracellular Ca2+ concentration. Notably, the role of traditional voltage-dependent Ca2+ channels (CaVs) in spermatogenesis, sperm maturation, motility, and preparation for egg fusion is not well defined. Sperm possesses a unique and very complex Ca2+ channel regulated by intracellular pH, Ca2+, and voltage called CatSper that is key for fertilization and influences motility, and possibly the acrosome reaction (AR). This exocytotic singular event encompasses the fusion of the acrosome vesicle in the posterior region of the head to the plasma membrane preparing this cell to fuse and fertilize the egg. Though CaVs and CatSper may participate in this reaction, it is still a pending question. In this chapter, we examine the characteristics of these Ca2+ channels and their involvement in sperm physiology.",

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AU - Treviño, Claudia L.

AU - Santi, Celia M.

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AB - As in most cell types, intracellular Ca2+ regulates many fundamental physiological functions in sperm and its progenitors. Ca2+ permeable and voltage-dependent channels in their plasma membrane deeply influence the intracellular Ca2+ concentration. Notably, the role of traditional voltage-dependent Ca2+ channels (CaVs) in spermatogenesis, sperm maturation, motility, and preparation for egg fusion is not well defined. Sperm possesses a unique and very complex Ca2+ channel regulated by intracellular pH, Ca2+, and voltage called CatSper that is key for fertilization and influences motility, and possibly the acrosome reaction (AR). This exocytotic singular event encompasses the fusion of the acrosome vesicle in the posterior region of the head to the plasma membrane preparing this cell to fuse and fertilize the egg. Though CaVs and CatSper may participate in this reaction, it is still a pending question. In this chapter, we examine the characteristics of these Ca2+ channels and their involvement in sperm physiology.

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Voltage-Dependent Calcium Channels (CaVs) and CatSper in Spermatogenic and Sperm Cells

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Keywords

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